Just as you should delete older dates from your resume, avoid referring to your 20 or 30 years of experience during an interview. It will instantly age even the hippest, most youthful-looking candidate.
If your kids are in college or older, or if you have grandchildren, do not mention it. You'll have plenty of time to discuss your kids after you get the job. No need to risk jeopardizing your chances prematurely.
And be aware of sneaky interview questions, like those designed to find out your year of graduation or your age. Although illegal, these can be brought up in a chummy, casual way, and then used against you.