6. "Can you explain this gap in your work history?"
Having a noticeable gap in your employment history isn't ideal, and it's probably going to count against you. But you still have a chance as long as you minimize the damage.
Did you leave the workforce because you were raising kids or taking care of a sick relative? The good news is many employers see value in that. However, that can't be the end of your explanation. You need to be sure to talk extensively about any volunteer work you did in that time, and spin it so it's positive and relevant to the position. For instance, if you're going for an accounting job and you spent a year as the treasurer of your child's PTA group, hit that hard. It tells the person interviewing you that even though you weren't employed, you were still keeping your skills fresh and remaining active.