Upstream Manager Scientist

DEPARTMENT DESCRIPTION The Upstream Development Group, as a part of the Manufacturing Technology Department, has responsibilities to support the development and continuous improvement of bioprocesses for manufacturing of Influenza, Meningitis, COVID, and other vaccines. It encompasses the development of seeds, production processes (Batch and Fed-Batch), evaluation, and improvements of process parameters. POSITION OVERVIEW/KEY RESPONSIBILTIES Primary responsibility will be to work as a part of the working virus bank (WVB) generation group. WVB is a recombinant baculovirus seed for manufacturing drug substances for Influenza & COVID vaccines. Day-to-Day Responsibilities: Maintenance of insect cells in suspension culture at different scales (shake flasks, waves, small and pilot size bioreactors) Transfection of insect cells, baculovirus plaque purification, infection & scale-up of baculovirus stocks Sampling cell culture and preparation of samples for analytical testing Performing standard molecular biology tasks such as baculovirus DNA purification, PCR, restriction endonucleases digest, DNA agarose gel electrophoresis Performing analysis of recombinant protein expression by Western blot, SDS-PAGE, and single radial immunodiffusion techniques (SRID) Responsible for completing paperwork for each task Maintenance of the labs and ordering of supplies Communicate with co-workers and present data on a regular basis at the group and department meetings Flexible in time management Complies with all company policies and standard BASIC QUALIFICATIONS Bachelor or Master's in biology, cell biology, molecular biology, biochemistry, chemistry, or related field. Experience in microbial and molecular biology techniques, procedures, and aseptic techniques. Ability to utilize Microsoft Excel, PowerPoint, and Word to perform tasks Fluent in both written and spoken English PREFERRED QUALIFICATIONS Experience in cell culture procedures and associated aseptic techniques Experience in molecular biology procedures Willing to work changing schedules and hours as needed Able to work effectively in a collaborative team Detail-oriented and able to prioritize assignments Strong verbal and written communication skills As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SP #LI-SP At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.