Postdoctoral Fellow, In Vivo Renal Disease Modelling

ROLE SUMMARY Pfizer’s In Vivo Functional Genomics Unit is seeking a highly motivated postdoctoral fellow who will lead our efforts to develop first-in-class mouse models for diabetic kidney disease. Under the guidance of research mentors and a Scientific Advisory Committee, the candidate will design a detailed research plan, work collaboratively within and beyond the unit to achieve the research goals, and share results via internal/external presentations and publications in high-impact journals. This is a unique opportunity to gain expertise in cutting-edge genome editing technologies for rodent model generation and develop deep experience in in vivo modeling of a devastating metabolic disease. ROLE RESPONSIBILITIES Independently design studies, execute experiments to produce high quality data utilizing technologies and resources available across Pfizer, and interpret results under the guidance of mentors. Effectively communicate results in internal and external forums and prepare manuscripts for publication in peer-reviewed journals. Participate in identification and expansion of genetically modified mouse models (GEMMs) internally created to model diabetic kidney disease. Apply surgical, pharmacological, dietary and other challenges to the GEMMs to best recapitulate the features of diabetic kidney disease. Work closely with collaborators in our Internal Medicine Research Unit and other groups to validate different study designs utilizing molecular, biochemical, histopathological, and other relevant analyses. Ensure all tasks and responsibilities are performed according to scientific and ethical standards, with full compliance with all regulatory requirements, and correctly documented in lab notebooks. QUALIFICATIONS Basic Qualifications Recent PhD in molecular biology, molecular genetics, biochemistry, pharmacology or related field with demonstrated productivity in independent research. 1-2 first-author publications (published or manuscripts submitted for publication) in high-quality specialty or general readership journals. Hands-on experience in working with in vivo disease models Demonstrated proficiency in basic molecular and biochemical techniques required, including some of the following: RNA/protein isolation from cells and tissues, qRT-PCR, Western blot, ELISA, immunostaining, flow cytometry, and RNA-seq. Excellent written and oral communication skills. Well organized, self-motivated, team oriented, ability to multitask with attention to detail. Preferred Qualifications Experience with in vivo renal or metabolic disease models Experience with small animal surgery and dosing Solid knowledge of genome editing and GEMM generation OTHER JOB DETAILS Must Have Work Authorization in US Eligible for Relocation Assistance Work Location Assignment: On Premise Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Research and Development Pfizer careers are like no other. In our culture of individual ownership, we believe in our ability to improve future healthcare, and potential to transform millions of lives. We’re looking for new talent to join our global community, to unearth new innovative therapies that make the world a healthier place.