Scientist, Cell Biology

About BridgeBioX and BridgeBio Pharma

Leveraging extensive inherited disease experience and an established drug development infrastructure, BridgeBio recently formed a discovery research group called BridgeBioX. The vision of BridgeBioX is to use cutting-edge biology to develop breakthrough medicines in genetic diseases with high unmet needs across multiple therapeutic areas including oncology, neurology, pulmonology, and cardiology. BridgeBioX is building out lab space on the Stanford Life Sciences campus to create a hybrid industry-academic environment where scientists from the top labs around the world can collaborate with senior BridgeBio leadership and advisors.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30 drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Who You Are

Do you want to join the next-level discovery team to test “moonshots” in genetic disease at BridgeBio? We seek a Scientist to work on high-risk, high-reward programs within a culture that celebrates failures as long as they are scientifically rigorous and conclusive. The projects within this team need someone with expertise and demonstrated track record in cellular assay development, biochemical assays, and biomarker analysis of in vitro and/or vivo samples.

You will lead discovery and development assays for some of the most challenging and high-impact genetic diseases and bring our early discovery and pre-clinical programs to the next level. If you have expertise in developing and optimizing various pre-clinical assays and want to be on the ground floor as we expand our internal capabilities at BridgeBio, we want to hear from you.

• Drive basic research toward the clinic at a fast pace
• Independently design, execute and analyze experiments within our top-notch laboratory
• Communicate findings and implications to small core teams and senior leadership
• Critically think about and help drive overall pre-clinical strategy 
• Use a variety of cellular, biochemical/biophysical, and pharmacological techniques to advance candidates from discovery research to clinical development

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

• Ph.D. or Ph.D./MD degree and expertise in a relevant scientific field (e.g., biochemistry, molecular biology, cell biology, chemical biology, structural biology)
• 1-3  years of postdoctoral experience (though excellent fresh Ph.D. graduates will be considered); industry experience is desirable but not required.
• Demonstrated record of achievement as evidenced by first-author publications, grants, fellowships/scholarships, or awards    
• Experience with the development of cell-based disease models through genetic manipulations, optimization, and scale-up of cellular assays with phenotypic and/or functional readouts
• Experience with molecular and cellular biology techniques, such as CRISPR gene editing, fluorescent/luminescent reporter assays, Lentivirus, qPCR, flow cytometry, Western blot, etc.   
• Experience working with and analyzing pre-clinical animal samples (e.g., plasma, liver) to probe treatment-associated pharmacodynamic readouts is highly preferable
• Experience with various protein purification techniques and plate-based biochemical/biophysical assays such as ELISA, TR-FRET, MSD, and enzymatic assays is desirable (but not required)  
• Experience with clinical (human) samples and biomarker development and validation would be a strong plus

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels seen, valued, and heard

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.