Immunohistochemistry Scientist - (6 month contract)

Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.

Responsibilities

• Establish histology/IHC expertise, including method development, protocol standardization and instrumentation, for the company using both internal and external resources
• Apply relevant histopathology techniques, including immunohistochemistry, flow cytometry, FISH, and molecular diagnostics in partnership with research and development scientists to discover and characterize drug mechanisms of action and novel biomarkers.
• Strong skill set in developing and implementing single and multiplexed immunohistochemistry methodologies from antibody selection, staining optimization
• Implement standard and novel techniques for histology, histochemistry, microscopy, immunohistochemistry (IHC), and in situ hybridization (ISH) experiments on non-human tissues.
• Train and oversee RAs and scientists on protocols, instrumentation and methodologies
• Prepare and maintain tissue fixatives and reagents/solutions for staining of tissue sections
• In collaboration with scientists, perform experiments requiring imaging and qualitative and quantitative analysis of staining      

Requirements:

• PhD in Cell or Molecular Biology, or similar field, with 3-5 years industry experience or MS in a relevant field with 8-10 years industry experience, or equivalent.
• Expertise in histological techniques such as processing, embedding, sectioning, histochemistry, immunohistochemistry,multiplexed immunofluorescence, and in situ hybridization
• Experience working with both human and animal tissue
• Track record of staying up to date with the latest developments in the field, including automated histology systems and data management.
• Excellent planning, organization and time management skills, including the ability to support and prioritize multiple projects and efficient use of ELN.
• Excellent verbal and written communication and skills
• Comfortable in a fast-paced team and able to adjust workload and responsibilities based on changing priorities
• Strong preference for candidates familiar with neuroanatomy and brain histology