What are the responsibilities and job description for the Principal Researcher position at Eisai?
At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai's human health care (hhc) mission. We're a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer's disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you.
Eisai has been dedicated for decades to the pursuit of novel therapeutics to improve the lives of people suffering from dementia and their families. Recognizing the potential for human genetics, data sciences and precision chemistry to disrupt the drug discovery paradigm, Eisai launched the Eisai Center for Genetics Guided Dementia Discovery (G2D2) in 2019 to accelerate the discovery of innovative therapeutics. G2D2 is a unique drug discovery organization driven by a diverse group of passionate, dedicated and collaborative scientists committed to one goal: delivering breakthroughs for patients and their families. All Eisai employees, as part of the company's human health care (hhc) mission, spend at least 1% of their working time with patients and families to ensure that the innovation we drive is based on an understanding of their real needs.
ThePrincipal Researcher, IHC will contribute to our discovery biology efforts by conducting a wide variety of immunohistochemical studies on tissues from animal models and humans. This person will be able to work independently and have sufficient background to be able to clearly present his/her experimental rationale, data, and analysis. Responsibilities include preparing tissues for sectioning, generating tissue sections by microtomy and cryotomy, designing, validating, and performing manual and automated immunohistochemistry, immunofluorescence and in situ hybridization experiments, imaging resulting slides by microscope or slide scanner, and analyzing the resulting images. Experience in neuroscience/ neuroinflammation is preferred. The ideal candidate should be well organized, proactive, possess excellent technical and communication skills, as well as the ability to work collaboratively in a team environment. Flexibility and willingness to learn and master new techniques are critical. We seek a creative and diligent person who brings care and attention to detail to the job.
Essential Functions
* Independently develop, optimize, and validate protocols for single and multiplexed immunohistochemistry, immunofluorescence and in-situ hybridization
* Prepare fixed tissue for sectioning
* Section frozen and paraffin embedded tissue samples and perform routine histology staining procedures
* Perform both manual and automated staining protocols
* Acquire images of stained sections using microscope (confocal, epifluorescence) or slide scanner
* Independently perform image analysis and quantification
* Generate accurate and detailed study reports and maintain other necessary records including a lab notebook.
* Independently identify and troubleshoot experimental roadblocks
* Participate in project team meetings
* Maintain laboratory equipment and reagent inventory
* Work well in a team environment
Requirements
* M.S. or B.S. plus 4-6 years relevant experience in Neuroscience, Pharmaceutical Sciences or other related field
* A background in neuroimmunology and/ or neurodegeneration is preferred
* Extensive experience with tissue embedding, tissue sectioning (microtomy and cryotomy), and manual immunohistochemistry and immunofluorescence staining is required
* Extensive experience with confocal, epifluorescence, and bright field microscopy required
* Experience with digital slide scanners (e.g. Leica Versa) preferred
* Experience with automated staining platforms (e.g. Leica BondRx and/or Ventana Discovery Ultra) preferred
* Experience with image analysis software (Imaris, Halo, Matlab, etc) strongly preferred
* Experience with pre-clinical species (e.g. mouse) required and experience with mouse brain sectioning/ staining preferred
* Excellent communication skills
* Detail oriented and highly motivated
Eisai is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, Eisai prohibits discrimination against persons because of disability, including disabled veterans.
Eisai Inc. participates in E-Verify. E-Verify is an Internet based system operated by the Department of Homeland Security in partnership with the Social Security Administration that allows participating employers to electronically verify the employment eligibility of all new hires in the United States. Please click on the following link for more information:
E-Verify Participation
Eisai is committed to a policy of equal employment opportunity for all employees and applicants. The Company also strives for a work environment free from discrimination and harassment. It is Eisai’s policy to comply with all applicable federal, state and local laws and regulations regarding nondiscrimination in employment and not to discriminate against any employee or applicant for employment on the basis of any protected status, including, but not limited to, race, color, national origin, religion, sex, age, disability, pregnancy, ancestry, creed, alienage or citizenship status, sexual orientation, gender identity and expression, marital status, military/veteran status, genetic information, or any other protected characteristic as established by law. Eisai is an Equal Opportunity Employer – Minority / Female / Disability / Vet
