Principal/ Senior Principal Scientist, Computational Chemistry

Genentech seeks a computational chemist with strong experience in structure-based drug design, ligand-based design, and cheminformatics to join our Computer-Assisted Drug Discovery group in the Discovery Chemistry Department. You will be an integral member of interdisciplinary drug discovery project teams, where you will apply computational chemistry, cheminformatics, machine learning, and artificial intelligence to help drive lead discovery, optimization, and development. You will also be involved in helping to improve our “best of breed” combination of computational chemistry and cheminformatics software applications and workflows. You will work closely with our Structural Biology, High Throughput Screening, DMPK, Safety/Investigational Toxicity, and other groups.

You will have access to state of the art modeling, simulation, and machine learning technologies as well as computing infrastructure, and be able to leverage rich collections of data to accelerate drug discovery in a fast-paced and creative environment. Based at our beautiful South San Francisco campus, you will join our computational chemists, cheminformaticians, and software engineers who are committed to discovering new medicines to address unmet medical needs. This is a tremendous opportunity to do meaningful work in an exciting, dynamic environment.

Who You Are

• Ph.D. or equivalent in Chemistry, Biochemistry, Biophysics, or other related disciplines

• Significant experience in computational chemistry, structure and ligand based design, modeling, and experience of designing molecules together with synthetic chemists is required

• Excellent interpersonal, verbal, and written communication skills and the ability to work collaboratively in teams

• Self-sufficient in scientific scripting and programming (e.g. Python)

• Practical, working experience with computational chemistry software from companies such as Chemical Computing Group, Dotmatics, Schrodinger, OpenEye, and Gaussian

• Knowledge of multivariate statistics, machine learning, deep learning approaches is desirable;

• 5 years of Industry experience in small molecule drug discovery is advantageous

Relocation benefits are available for this position

The expected salary range for this position based on the primary location of California is $144,340 and $268,060. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

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