Investigator

We currently have a vacancy on our team for an NMR spectroscopist focusing on small molecule structure elucidation. This is an exciting opportunity for an enthusiastic individual to join an NMR-focused team within a multi-disciplinary analytical department, delivering expert solution-state NMR support to a range of projects from early discovery through late-stage development. Applications in small molecules, oligonucleotides, protein therapeutics and drug products will all form part of this exciting role.

Working in a flexible NMR team, the successful candidate will undertake NMR analyses, including structure elucidation, conformational analysis, mixture analysis and more, supporting problem solving and product development from multiple projects with diverse challenges. The successful candidate will also work alongside other multi-faceted scientists as part of cross-functional project teams and will work with a high level of autonomy and accountability, contributing to regulatory submissions and overseeing the completion of work packages to deadlines.

Has a role under guidance of the Team Leader to:
* Provide knowledge and expertise in NMR, structure elucidation and reaction mechanisms to support the discovery and development of drug candidates
* Provide expertise, knowledge and strategic vision to enhance and expand NMR experimental approaches in structure elucidation including tailored approaches to meet the specific needs of stakeholders.
* Provide technical and scientific creativity in resolving non-routine issues associated with structure identification studies
* Serve as a mentor to team in developing scientific expertise
* Troubleshoot experimental and instrumental issues
* Comply with the requirements of Quality, Safety and GSK policies and procedures and ensure that GSK intellectual property is protected.

Further expectations:
* Contribute to and effectively work within matrix teams comprised of colleagues from both within and outside of their own department
* Self-motivated flexible approach with good organizational skills and ability to communicate in a scientific manner.
* Evaluate potential innovative research areas and/or apply innovative solutions to projects.
* Successful record of influencing, mentoring and developing colleagues.
* Contribute to regulatory dossiers and author/review expert reports

We are looking for professionals with these required skills to achieve our goals:

• Ph. D. with 5 years or a Masters degree with 10 years of NMR experience in small and/or large molecule structure elucidation.
• Experience with the state-of-the-art NMR instrumentation in order to provide key information for projects at all stages of pharmaceutical discovery and development.
• Experience in NMR spectroscopy and structure elucidation; demonstrated ability to apply 1D, 2D and heteronuclear NMR techniques specifically to the structural elucidation of small molecules (e.g., impurities/degradants/metabolites) and/or large molecules (e.g., oligonucleotides, proteins, monoclonal antibodies).
  

If you have the following characteristics, it would be a plus:

• Educated and trained in Pharmaceutical or Chemical Sciences
• Demonstrated expertise in modern NMR pulse sequence programming and AU/macro programming on Bruker spectrometers.
• Experience in structure elucidation software (e.g. ACD) for NMR.
• Expertise in automated sample preparation, acquisition, and data analysis.
• Demonstrated ability to utilize NMR techniques to characterize oligonucleotides, proteins, and monoclonal antibodies.
• Knowledge of closely related scientific disciplines as they apply to drug discovery and development (e.g., solid-state NMR, mass spectrometry, vibrational spectroscopy, XRPD).
• Demonstrated ability to integrate spectroscopic and other scientific data into the processes of structure elucidation.
• Demonstrated ability to deliver this scientific knowledge within and beyond their scientific discipline.
• Flexible thinking and demonstrated ability to innovate in creating options and solutions required in solving challenging problems.
• Experience with the overall drug development process, including GxP requirements.
• Demonstrated excellence in both oral and written communication.
• Demonstrated ability to proactively build networks and relationships that instill confidence, trust, and teamwork.
• Demonstrated knowledge and application of Digital, Data and Analytics principles, tools, and approaches.

#LI-GSK

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