What are the responsibilities and job description for the Scientist II position at Lyell Immunopharma?
Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. At Lyell, our goal is to change that. We are a clinical-stage T-cell reprogramming company advancing a diverse pipeline of cell therapies for solid tumors based on our innovative technologies. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to defeat solid tumors, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.
POSITION SUMMARY:
We are seeking an experienced talent to join our R&D team in South San Francisco as a Scientist II on the T Cell Stemness team. The ideal candidate will skilled and accomplished in their field and initiates, directs and executes all scientific research and development strategies independently. Works with the team to investigate the feasibility of applying a wide variety of scientific principles and concepts to solve problems. Tasked with leading large projects under guidance (cross functional technical core- related projects or scientific projects), designing direction, goals, the timelines and experiments, and regularly presents data to leadership. Responsible for keeping abreast of current publications in their field and can independently integrate ideas from these publications into current projects. Networks with colleagues outside their own area of expertise. Responsible for carrying out a variety of experiments within multiple areas of focus. Mentors and may supervise junior colleagues (or lead core groups) in the planning and execution of laboratory research.
KEY ROLE AND RESPONSIBILITIES:
- Design complex experiments under guidance while executing independently with scientific rationale
- Design, execute and critically analyze experiments independently and interpret complex data drawing appropriate conclusions
- identify new technical areas of study and propose projects/assays to be evaluated by leadership. Thinks creatively to make experiments and assays more refined and efficient; develops SOPs and establishes business workflows and reaches out independently to integrate ideas from other groups
- Responsible for the completion of research, experiments and assignments that have an impact on functional/technical goals
- Communicate and discuss results with other scientists
- Deliver presentations and contributes to abstracts, posters or publications, both internally and externally
- Mentor and possibly manage junior associates
- Work independently with their team on a variety of complex assays
- Explore new idea for product development from scientific literatures
- Analyze situations or data that require an in-depth evaluation of variable factor
- Exercise independent judgment in selecting methods, techniques and evaluation criteria for obtaining results
- Carry out a variety of experiments within multiple areas of focus
- Keep current on innovation happening in the field
- Learn new techniques which are useful in getting data to support current projects.
- Network with colleagues outside own area of expertise
- Generate, maintain and review of electronic lab notebook reports and SOPs
- Responsible for the completion of research, experiments and assignments that can have an impact on functional goals
- Communicate data with supervisor
- Collaborate and mentor research associates
PREFERRED EDUCATION:
- BSc in immunology, oncology or related field with a minimum of 11 years’ experience within the area of focus; or
- MSc in immunology, oncology or related field with a minimum of 9 years’ experience within the area of focus; or
- PhD in immunology, oncology or related field with a minimum of 4 years’ experience within the area of focus.
PREFERRED EXPERIENCE:
- Mammalian cell culture, preferably experience culturing primary human immune cells, T cells
- Cell-based in vitro assays
- Experience with multi-parameter flow cytometry
- Experience in process science
- Experience exploring new biomarkers
- Molecular biology (PCR, western blot, DNA/RNA isolation, quantification)
- Assessing T cell functionality in vitro and in vivo
- Experience with molecular biology protocols (i.e. PCR, Western, RT-PCR, basic cloning); more complex experience and design
- Extensive experience using and analyzing broad range of immunology and oncology assays; cell therapy experience ideal, more complex experience
- Extensive experience with flow cytometry assays and analysis; more complex analysis and cell sorting experience
- Extensive experience in sterile tissue culture technique and working with human cells
- Additional specific experience related to the area of focus may be required
- Additional experience with Tumor infiltrating lymphocytes (TIL) culture and TIL specific expertise
- Experience with T cell metabolism
KNOWLEDGE, SKILLS AND ABILITIES:
- Data analysis
- Proficiency in data analysis using Prism, Excel or equivalents required
- Proficiency using office software such as Word, Powerpoint or equivalents to generate reports and presentations required
- Experience using FlowJo for analysis and interpretation of flow cytometry data is strongly preferred
- Ability to thrive within and contribute to a collaborative, supportive, fast-paced team environment
- Ability to stand or sit for extended periods of time may be necessary
Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.
The salary range for this position is $135,000 to $150,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found here.
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
Salary : $135,000 - $150,000
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