Distinguished Scientist DMPK Project Expert

Sanofi is seeking a highly experienced scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) research platform of the North American Hub. This role is currently based in Waltham but will move to Cambridge in 2022 and will be a hybrid role that allows for work on-site and remotely.

Key Responsibilities:

• Represent DMPK on preclinical development projects to ensure effective integration of DMPK science into the company’s strategy of developing first and best in class therapies for Oncology, Inflammatory and Rare/Neurological diseases.

• Contribute to the project team strategy at the early discovery phase up to first in human (FIH) trials

• Characterize ADME and PK properties of small molecules, biologics and/or gene therapies

• Aid in the development of PKPD strategies for preclinical development programs

• Conceive and implement the preclinical strategy for predicting human efficacious and safe starting dose levels for first in human clinical trials

• Mentor junior scientists on ADME and PKPD strategies and their applications in pre-clinical drug development

• Contribute to the writing and submission of regulatory documents.

Requirements:

• Ph.D. in Pharmacokinetics or other relevant field with a minimum of 10 years of relevant experience, OR Master’s degree and 18 years of relevant experience, OR Bachelor’s and 18 years of relevant experience​.

• Demonstrated ability to drive and lead ADME and PKPD strategies for discovery project teams

• The ability to function in a matrix environment and communicate with a diverse set of ever-changing individuals is a must

• Experience with multiple drug modalities including small molecules, biologics and gene therapies

• Strong written, presentation and verbal communication skills

• The ability to conduct non-compartmental analysis (NCA) for non-GLP PK and TK reports is required

• Ability to conduct PKPD analysis is a must

• Experience with the preparation of documents for regulatory submission (IND/IMPD/CTX) is a plus

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society. 

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.  

#GD-SG
#LI-GZ

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.