Principal Bioinformatics Scientist

Principal Scientist, Bioinformatics – SeQure Dx, Inc.

SeQure Dx, Inc. is applying state of the art genomics technologies for CRISPR gene editor target profiling to advance discovery, clinical development, and diagnostic solutions. Our technologies provide the foundation needed to ensure that life-saving gene therapies will be both safe and effective. This is a rare opportunity to engage with established leaders in the field and become part of a dynamic team at an early-stage company with substantial opportunities for growth and career development. Our Waltham, MA facility is conveniently located and offers many amenities in the building and nearby community. SeQure Dx offers competitive benefits and is an Equal Opportunity Employer.

Job Description

We are looking for a motivated and agile Principal Bioinformatics scientist to develop pipelines and perform analyses on CRISPR gene editing datasets, primarily focusing on off-target mutation and rearrangement analysis.

Responsibilities

• Develop bioinformatics pipelines by integrating and extending existing bioinformatics and next-generation sequencing (NGS) tools
• Develop and run Python and R based pipelines in HPC environment in cloud.
• Interact effectively with cross-functional teams, including research, clinical and lab scientists to develop assay and computational capabilities in tandem
• Analyze and maintain human population scale genetic variant datasets
• Stay current with new bioinformatics analysis tools and software technologies,

Basic Qualifications

• PhD in Bioinformatics, Computer Science, Statistics or a related field, or Master’s degree with at least 5 years of industry experience
• Strong bioinformatics skills in genomics, specifically involving NGS sequence analysis for amplicon, exome, and/or whole genome sequencing.
• Experience with a variety of programming languages. (preferably R, Python), and AWS cloud environment (EC2, S3, dockers, WDL/CWL etc.)
• Best-practice software development experience (e.g. git, unit testing)

Preferred Qualifications

• Familiar with the CRISPR technology and off-target assessment methods such as GUIDE-Seq and CIRCLE-Seq.
• Experience in developing visualization tools using RShiny or similar methodology

• Experience with statistical and/or machine learning methods
• Database management

Job Type: Full-time

Pay: $106,354.00 - $187,439.00 per year

Benefits:

• 401(k)
• 401(k) matching
• Dental insurance
• Health insurance
• Paid time off
• Vision insurance

Schedule:

• Monday to Friday

Supplemental Pay:

• Bonus pay

Education:

• Doctorate (Preferred)

Experience:

• Research: 5 years (Preferred)

Work Location: One location