Senior Manager, Environmental, Health and Safety (EHS)

Company Profile:

Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte's lead candidate, VAX-24, is a 24-valent, broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company's system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte's pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of greater than 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit www.vaxcyte.com.

Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 150 employees and anticipates continued, significant growth. Following the October 2022 follow-on equity offering, which generated approximately $651 million in net proceeds, the Company's balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. On October 24, 2022, the Company announced positive topline safety, tolerability and immunogenicity data from the Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children. VAX-24 is being investigated for the prevention of IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte's PCV franchise, consisting of VAX-24 and VAX-XP, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease. We believe that our PCVs could receive regulatory approval based on successful completion of clinical studies utilizing well-defined surrogate immune endpoints, consistent with how other PCVs have obtained regulatory approval in the past, rather than requiring clinical field efficacy studies.

Summary:

Vaxcyte is seeking a talented, pro-active, and self-motivated individual to join our growing Facilities and Lab Operations Team. The Senior EH&S Manager is a very hands-on role and is responsible for the overall EH&S compliance program for Vaxcyte laboratories and offices including, lab safety, regulatory compliance, training, and ergonomics. The Senior EH&S Manager is a critical point of contact for lab personnel, fielding safety questions, and helping to drive and maintain a culture of safety and compliance.

This role will be instrumental in ensuring our facilities and lab operations department and laboratories are ready for growth with Vaxcyte's current and projected product pipelines. This department enables the labs to run efficiently and the scientists to focus on delivering their respective pipelines. This role will support this department's transformational journey including centralizing lab operations, standardizing common services, consolidating supplies, implementation of GMP and contracts and application of lean lab techniques (e.g., 5S, Kanban, visual management). A successful candidate is well organized, flexible, creative and enjoys the challenges of managing a diverse and energetic office space. This is a full-time, on-site role that reports to the Director of Lab Operations.

Note: rotational, shared 24x7 support is required of this role.

Essential Functions:

• Reviews and implements corporate EH&S programs, policies, procedures, training and reporting.
• Champions organizational compliance, evaluating workplace environments, equipment and practices of all safety standards and applicable regulations.
• Guides management of hazards associated with process safety management, ensuring a comprehensive program is maintained to integrate technologies, procedures and management practices.
• Responsible for chemical inventory management and SDS documentation.
• Conducts chemical and SDS risk assessment as well as operations risk assessment to specific controls and other regulatory requirements are applicable.
• Develops and implements environmental strategies in the workplace, auditing and analyzing environmental practices fur sustainability (including workplace pollution control, waste management and recycling).
• Undertakes regular statutory compliance audits, job safety analysis, process safety management of safety programs and systems.
• Directs accident investigation programs, reports or reviews findings, note trends and develop programs (Corrective and Preventive Actions (CAPA)) for improving performance.
• Responsible for providing and communicating employee and lab safety training, Emergency Response (Emergency Action Plan (EAP)), and health and safety plans.
• Responsible for all Environmental, Health and Safety programs including, but not limited to: Emergency Response, Emergency Action Plans, Respiratory Protection Plan, Injury and Illness Prevention Program (IIPP), Ergonomics, etc.
• Sets environmental and safety priorities and goals consistent with company objectives.
• Specifies EH&S guidelines and directives for internal governance and internal controls.
• Establish cross functional team (safety committee) to coordinate delivery of compliance, safety performance.
• Defines solutions which support EH&S policy integration into office and lab operations.
• Determines improvement which provide reliable, successful EH&S programs.
• Serve as Vaxcyte's EH&S owner.
• Develop waste collection and disposal procedures to meet evolving needs and regulatory requirements.
• Manage contracts with external service providers for chemical and biological waste and all other position related services.
• Coordinate with Radiation Officer to ensure all applicable Radiation Lab requirements and regulations are met and maintained.
• Maintain accurate waste records as applicable to Vaxcyte.
• Generate operational definitions that govern both safety and productivity.
• Partner with Biological Safety Officer to implement a Biological Safety Program.
• Maintains required lab and employee EH&S training records.
• Works with landlord to ensure Vaxcyte EH&S polices, practices and training align with property management requirements.
• Leads the Emergency Response Team (ERT).

Requirements:

• Bachelor's degree in science or engineering related discipline.
• 5-7 years of progressive experience in laboratory operations experience managing and scaling lab operations in a biotechnology or pharmaceutical research environment.
• Previous experience in managing EH&S programs for both offices and laboratories.
• Customer service oriented and has a track record of anticipating the needs of all customers, including bench scientists and office employees.
• Demonstrated drive, curiosity, scientific rigor, and excellent problem-solving skills across a fast-paced performance driven environment.
• Ability to operate effectively at both an operational and strategic level.
• Ability to constructively challenge, improve and develop lab operations practices and processes.
• Self-motivated with the proven ability to take ownership and deliver results in an environment with ambiguity and change.
• Ability to collaborate cross functionally and align stakeholders to a common problem or solution.
• Strong communication and interpersonal skills - Oral, written and formal presentation skills.
• Demonstrated ability to develop new safety practices (from a blank sheet of paper) and standard operating procedures.
• Highly effective communication and organization skills.
• Proven collaboration and teamwork skills and experience in a fast-paced environment.
• Creative and proactive problem solver; keen ability to anticipate needs in a lab environment, solving problems with sound judgment.
• Experience managing and prioritizing inputs from diverse stakeholders to deploy a plan that meets the needs of the business.
• Proficiency planning and managing small projects.
• Proficient in GMP, GLP, and GDP.
• All Vaxcyte employees require vaccination against COVID-19.

Reports to: Director of Lab Operations

Location: San Carlos, CA

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Send resumes to:

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Vaxcyte, Inc.

825 Industrial Road, Suite 300

San Carlos, CA 94070