Postdoctoral Research Fellow - Biology

Wave Life Sciences (Wave) is a biotechnology company focused on delivering transformational therapies for patients with serious, genetically defined diseases. We differentiate ourselves through our proprietary chemistry platform that enables the production of stereopure oligonucleotides precisely targeting the underlying cause of rare diseases. At Wave, we welcome those who share a passion to change lives and embrace a culture that is thoughtful, dynamic, humble, and fearless. Together, we can contribute to our mission enabling every patient with a genetic disease to have access to life changing treatments.

Wave seeks a highly motivated postdoctoral research fellow to join its team in Cambridge, MA. This is an ideal position for an individual with an interest in developing RNA-based therapeutics who thrives in a team-oriented, fast-paced, and cross disciplinary biotech environment. The main area of focus for the project will be in the forefront of basic research into RNA epigenetic modifiers and how to perturb them using chemically designed small oligonucleotide therapeutics. The candidate will be an integral member of a small team of scientists aiming to rapidly and pragmatically realize the potential of a novel oligonucleotide therapeutics platform.

Responsibilities
Work with scientists in the biology team to advance an early stage RNA targeting technology

• Plan and execute experiments to optimize oligonucleotide design for the purpose of perturbing RNA modifications/epigenetic modifications across multiple different tissue and cell models
• Rationally apply Wave’s proprietary PRISM platform to improve oligonucleotide efficacy and design
• Execute in vivo and in-vitro assays to characterize changes in the RNA epigenetic landscape and biochemical properties of the cellular RNA epigenetic machinery.
• Prepare clearly articulated experimental reports and data presentations
• Attend and contribute to discussions in weekly internal team meetings
• Publish findings in high-quality peer reviewed scientific journals and/or relevant conference

Qualifications

• Recent or upcoming graduate with a PhD in biochemistry, cell biology, molecular biology or related field
• Experience with mammalian cell culture including transfection, RNA isolation, qPCR, etc.
• Experience in studying RNA epigenetics is desired but not required
• Familiarity with next generation sequencing methods and oligonucleotide therapeutics (antisense, siRNA, exon-skipping, etc.) is a plus
• Ability to innovate and think creatively to support and advance platform & drug development processes
• Effective communication and interpersonal skills
• Strong presentation skills; adept at presentation of clear and accurate reports for internal and external projects
• Excellent organizational skills with an ability to embrace change and multi-task in an extremely fast paced environment
• Collaborative and self-motivated team player

Throughout the global pandemic, Wave has been committed to ensuring the safety of all employees and their families, while continuing to move the business forward so that we can deliver on our commitment to patients. We have implemented an approach to COVID-19 that is informed by the science and aligns to recommendations established by the CDC and other applicable government health agencies. To that end, Wave has implemented a mandatory COVID-19 vaccination policy that requires its employees to be vaccinated to the maximum extent permitted by applicable law.

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.