DENALI THERAPEUTCS INC

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. The company offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidates, including DNL201 and DNL151, which are in Phase 1 clinical trials for Parkinson's disease. It is also developing receptor interacting serine/threonine protein kinase 1 (RIPK1) product candidates, such as DNL747, a selective and brain-penetrant small molecule RIPK1 inhibitor product candidate that is in Phase 1b clinical trial for Alzheimer's disease and amyo ... trophic lateral sclerosis (ALS). In addition, the company develops enzyme transport vehicle: iduronate 2-sulfatase, an enzyme replacement therapy program for MPS II, a lysosomal storage disorder; antibody transport vehicle (ATV): alpha-synuclein (aSyn) program, a protein that spreads throughout the brain in Parkinson's disease; ATV: triggering receptor expressed in myeloid cells 2, a therapeutic candidate designed to rescue microglial function in Alzheimer's disease; and ATV: Tau, a therapeutic targeting the spreading of Tau. Further, it is developing LF1, an undisclosed large molecule program to treat neurodegenerative diseases. Additionally, the company has various seed programs under the research, discovery, and preclinical stages of development. Denali Therapeutics Inc. has collaboration agreement with Takeda Pharmaceutical Company and Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is based in South San Francisco, California. More

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Headquartered in South San Francisco, CA
Total Employees 200 - 500
Company Earnings $10M - $50M
Industry Biotechnology

Popular Jobs at  DENALI THERAPEUTCS INC

Administrative Project Coordinator. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Opportunity. Denali Therapeutics is seeking to recruit an experienced Administrative Project Coordinator who will provide programmatic support of a substantial and confidential nature. Responsibilities (include but are not limited to the following). Partner and coordinate activities for the Talent Acquisition Team: Includes management of a complex calendar, coord... view job details

Associate Director Quality Assurance – Document Management. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Opportunity. Reporting to the Senior Director and Head of GMP and GLP Quality Assurance and Quality Control, the Associate Director of QA will provide quality oversight of Denali’s document management system as well as being the quality superuser of MasterControl™ for our electronic document management system. This role will also contribut... view job details

Associate Director Quality Assurance – Small Molecule Technical Quality. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Opportunity. Reporting to the Senior Director and Head of GMP and GLP Quality Assurance and Quality Control, the Associate Director of QA will provide quality oversight of Denali’s external manufacturing and laboratory network (CMO/CLOs) and support internal/external CMC development activities. This role will also contribute t... view job details

Associate Director, Analytical and Formulation Development. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology, principles of translational medicine, and excellence in technical development. The Opportunity. As Denali builds internal capabilities to support rapid process and formulation development for our diverse pipeline of large molecules, we are seeking a talented and motivated Principal Scientist to provide strategic technical leadership to analytical development and extended characteriza... view job details

Associate Director, Clinical Business Operations. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.. The Opportunity. Reporting to the Director of Clinical Outsourcing, the Associate Director will lead, manage and oversee clinicalbudgets and forecasts for Denali’s Clinical Operations groups and other cross-functions within Development. This role will also partner with Denali Finance to contribute to overall financial planning and analysis for Denali’s... view job details

Associate Director, Finance. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Opportunity. Denali Therapeutics is seeking to recruit an Associate Director, R&D Finance. Reporting to the Head of R&D Finance, this position will advise functional business units & project teams to guide the growth of the company.  The individual in this role will be responsible for leading the annual budget, long-range plan, and quarterly forecasts. The individual wi... view job details

Associate Director, Quality Assurance. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Opportunity. Reporting to the Senior Director and Head of GMP and GLP Quality Assurance and Quality Control, the Associate Director of QA will provide quality oversight of Denali’s external manufacturing and laboratory network (CMO/CLOs) and support internal/external CMC development activities. This role will also contribute to establishing the internal qualit... view job details

Associate Director, Toxicology. at Denali. South San Francisco. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali Therapeutics is seeking to recruit a Associate Director of Nonclinical Safety (Toxicology). The Toxicologist will lead safety strategies for small and large molecule discovery and development programs, and work in close collaboration with colleagues in Research and Development. Responsibilities. Function as a project toxicologist in... view job details

Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Opportunity. The Company is seeking to hire an Associate Scientist in support of small molecule and biomarker bioanalysis efforts within the DMPK group. The successful candidate will work closely with DMPK/... view job details

Associate Scientist, DMPK. Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Opportunity. The Company is seeking to hire an Associate Scientist, DMPK, with passion and commitment to contributing to small molecule drug discovery and early development.  The incumbent will generate impactful data related to biotransformation, metabolism enzymology, and pharmacokinetics that will identify and advance lead drug candidates. The role requires knowledge o... view job details