ACCELERON PHARMA INC Clinical Site Manager Salary in the United States

How much does a Clinical Site Manager make at companies like ACCELERON PHARMA INC in the United States? The average salary for Clinical Site Manager at companies like ACCELERON PHARMA INC in the United States is $81,940 as of May 25, 2023, but the range typically falls between $70,695 and $93,184. Salary ranges can vary widely depending on many important factors, including education, certifications, additional skills, the number of years you have spent in your profession. With more online, real-time compensation data than any other website, helps you determine your exact pay target.  View the Cost of Living in Major Cities


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What does a Clinical Site Manager do at companies like ACCELERON PHARMA INC?

Who are we?

Acceleron is a biopharmaceutical company dedicated to the discovery, development, and commercialization of therapeutics to treat serious and rare diseases. The Company's leadership in the understanding of TGF-beta superfamily biology and protein engineering generates innovative compounds that engage the body's ability to regulate cellular growth and repair.

Acceleron focuses its research and development efforts in hematologic, neuromuscular, and pulmonary diseases. In hematology, the Company and its global collaboration partner, Celgene, are co-promoting newly approved REBLOZYL® (luspatercept-aamt) in North America for the treatment of anemia in adult patients with beta thalassemia who require regular red blood cell transfusions and developing luspatercept for the treatment of chronic anemia in myelodysplastic syndromes and myelofibrosis. Acceleron is also advancing its neuromuscular program with ACE-083, a locally-acting Myostatin+ agent in Phase 2 development in Charcot-Marie-Tooth disease and is conducting a Phase 2 pulmonary program with sotatercept in pulmonary arterial hypertension.

What will you be doing?

The Clinical Site Manager (CSM) will serve as a site-facing Clinical Operations resource responsible for the performance of the investigative sites.
The CSM will serve as an interface between Acceleron clinical study team, and vendors to ensure quality and timely study execution at the site level. The CSM will be responsible for cultivating and fostering long-term relationships with clinical trial site personnel to help position Acceleron as a sponsor of choice. In addition, the CSM will support the effective CRO interactions with study sites by developing relationships with key CRO personnel and supporting the development of effective processes and communication between the CRO and Acceleron as well as the CRO and clinical trial sites. The CMS will contribute to the development, implementation, and oversight of novel monitoring approaches such as risk-based monitoring, remote data review, and key risk indicator review/action.

  • Works proactively and in close collaboration with Acceleron/CRO clinical study teams, the CSM will perform study activities, including but not limited to the following:
  • Serve as Acceleron point of contact for investigative sites and establish regular lines of communication.
  • Responsible for management and oversight of activities performed by Clinical Research Associates (CRAs) including site management and site monitoring.
  • Evaluate CRA quality and performance via key performance indicators; oversight of CRA trip reports and action items.
  • Facilitate development of CRA/site training materials; participate in CRA training activities
  • Establish site selection criteria with cross-functional team. Responsible for site evaluation and selection.
  • Develop patient recruitment and retention initiatives; ensure full leveraging of recruitment and retention tactics by CROs and clinical sites;
  • Strategically reviews protocols to ensure operational clarity for investigator sites; collaborates with the Clinical Study Team (CST) to develop the baseline timelines and milestones
  • Engage study site personnel (i.e., PI, SI, study coordinators, other HCPs, etc.) in discussions to: maintain focus on overall study design, rationale, and eligibility criteria; identify operational hurdles/challenges and offer potential strategic solutions; apply mitigations broadly between sites and across studies ensure quality execution of clinical studies
  • Participate in monitoring visits with CRA to assist with site management, quality oversight, and site relationship enhancement; may visit investigator sites without CRO personnel
  • Perform protocol deviation tracking, trending and assessment of preventative action effectiveness, and assessment of risks through Key Risk Indicators (KRIs)
  • Collaborate and align with study Clinical Trial Managers, MDs, Clinical Science, Medical Affairs, and Commercial on clinical investigator engagement
  • Is a member of the Clinical Study Team and attends CRO CRA meetings
  • Proactively addresses issues with data collection, management, protocol execution. Identify and proactively mitigate challenges related to protocol conduct at study sites
  • Conduct and document Sponsor monitoring oversight activities.
  • Conduct risk assessment categorization activities with cross-functional study team, including protocol- and site-level risk assessments.
  • Identify and develop needed internal procedures
  • Identify, communicate and implement lessons learned across sites, regions and studies
 What are we looking for?
  • 5-7 years of combined clinical monitoring and clinical operations study management experience in the biotech/pharmaceutical industry
  • Minimum of 4 years of field monitoring and management within the biotech/pharmaceutical industry performing pre-study visits, initiation, interim and close out visits
  • Minimum of 1 year a CRA Manager, Lead CRA or Project Manager;
  • Knowledge of local and Health Authority regulatory requirements and ICH GCPs
  • Ability to develop robust knowledge of protocol, program goals, disease area, competitive landscape
  • Demonstrated customer service and relationship building skills with clinical sites (onsite and remote)
  • Ability to convey scientific and medical information to a diverse audience; ability to translate clinical research objectives to strong and clear operational plans.
  • Strong vendor management skills; experience developing/implementing processes and performance indicators
  • Strong written and verbal communication skills; effective collaboration, interpersonal and organizational skills
  • Ability to resolve issues independently but escalating where necessary
  • Must be tactful, mature, flexible, and have well-developed interpersonal skills. Ability to get along well with different personalities and to work well in teams.
  • Relevant clinical experience and scientific degree/background; rare disease clinical research experience desirable
  • Excellent negotiation, influencing, and problem solving skills
  • Ability to travel extensively


*In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and complete the required employment eligibility verification document form upon hire.
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Understand the total compensation opportunity for Clinical Site Manager at companies like ACCELERON PHARMA INC, base salary plus other pay elements

Average Total Cash Compensation

Includes base and annual incentives

The chart shows total cash compensation for the ACCELERON PHARMA INC Clinical Site Manager in the United States, which includes base, and annual incentives can vary anywhere from $70,695 to $93,184 with an average total cash compensation of $81,940. Total compensation includes the value of any benefits received in addition to your salary and some of the benefits that are most commonly provided within a total compensation package including bonuses, commissions, paid time off, and Insurance. The total cash compensation may get paid differently by industry, location, and other factors.
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