Principal Scientist, Medicinal Chemistry Salary in the United States

How much does a Principal Scientist, Medicinal Chemistry make in the United States?

As of January 01, 2026, the average salary for a Principal Scientist, Medicinal Chemistry in the United States is $142,955 per year, which breaks down to an hourly rate of $69.

However, a Principal Scientist, Medicinal Chemistry's salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $175,152
  • Majority Range (25th-75th percentile): $131,920 to $159,808
  • Entry-Level (10th percentile): $121,873
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View as table View as graph 25% $131,920 10% $121,873 90% $175,152 75% $159,808 $142,955 50%(Median) Didn’t find job title? Click

Principal Scientist, Medicinal Chemistry Salaries by Percentile

Annual
Salary		 Monthly
Pay		 Weekly
Pay		 Hourly
Wage
75th Percentile $159,808 $13,317 $3,073 $77
Average $142,955 $11,913 $2,749 $69
25th Percentile $131,920 $10,993 $2,537 $63
Check out Principal Scientist, Medicinal Chemistry Job Openings in the United States
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Medical Laboratory Scientist

Sonora Quest Laboratories - PHOENIX, AZ

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Key Factors That Influence Principal Scientist, Medicinal Chemistry Salaries

A Principal Scientist, Medicinal Chemistry's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location, education and company size can directly affect your earning potential.

How Do Principal Scientist, Medicinal Chemistry Salaries Vary from State to State?

Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Principal Scientist, Medicinal Chemistries. For example, consider the average annual salaries in these key locations:

  • District of Columbia: $158,280.
  • California: $157,679.
  • Massachusetts: $155,578.

Top Paying Cities for Principal Scientist, Medicinal Chemistries

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $180,309
  • San Francisco: $178,536
  • Oakland: $174,577

What Skills Can Increase a Principal Scientist, Medicinal Chemistry's Salary?

Demanded Skills for the Role:

  • Analysis (Mentioned in 11.04% Job Postings): Analysis is the process of considering something carefully or using statistical methods in order to understand it or explain it.
  • Immunology (Mentioned in 3.3% Job Postings): Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through various lines of defence.
  • Drug Discovery (Mentioned in 1.94% Job Postings): The process of identifying chemical entities that have the potential to become therapeutic agents. Recognition of new molecular entities that may be of value in the treatment of diseases that qualify as presenting unmet medical needs.
See More Skills
Skills Demand Percentage
Analysis 11.04%
Immunology 3.3%
Drug Discovery 1.94%
What skills can make your compensation higher?
Mastering certain specialized skills can lead to a significant increase in pay. Here are examples of skills and the potential impact they can have on a Principal Scientist, Medicinal Chemistry's salary.
  • Oncology: Can increase your salary by up to 6%.
  • Immunology: Can increase your salary by up to 5%.
  • Drug Discovery: Can increase your salary by up to 5%.
Skill Salary Salary % Increase
Oncology
 $151,532
6%
Immunology
 $150,103
5%
Drug Discovery
 $150,103
5%
Cell Biology
 $148,673
4%
Biotechnology
 $147,244
3%
Molecular Biology
 $147,244
3%
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How Education impacts a Principal Scientist, Medicinal Chemistry's Salary?

Your level of education can impact your salary potential. While many Principal Scientist, Medicinal Chemistries enter the field with a JD, MD, PhD or Equivalent degree, higher education can lead to more specialized and higher-paying roles.

According to our 100% employer-reported salary data, the median salary for a Principal Scientist, Medicinal Chemistry with a JD, MD, PhD or Equivalent is between $147,037 and $155,559).

Principal Scientist, Medicinal Chemistry Salaries by Degree Level

Typical Education for Principal Scientist, Medicinal Chemistry
Degree Level % of user with this level of education
No Diploma 0.2%
High School 0.2%
Associates 0.2%
Bachelors 6.6%
Masters 8.6%
Doctorate 84.4%
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Principal Scientist, Medicinal Chemistry Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Principal Scientist, Medicinal Chemistry's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

  • Hourly
  • Monthly
  • Weekly
  • Yearly
  • Table View
Last Updated on January 01, 2026
$131,920
Average $142,955/year
$159,808
$10,993
Average $11,913/month
$13,317
$2,537
Average $2,749/week
$3,073
$63
Average $69/hour
$77
Annual Salary Monthly Pay Weekly Pay Hourly Wage
75th Percentile $159,808 $13,317 $3,073 $77
Average $142,955 $11,913 $2,749 $69
25th Percentile $131,920 $10,993 $2,537 $63

Salaries of jobs related to Principal Scientist, Medicinal Chemistry

Salary Trends for Principal Scientist, Medicinal Chemistry

Salaries for a Principal Scientist, Medicinal Chemistry can change over time, reflecting shifts in market demand and the overall economy. The median salary decreased from $111,606 in 2023 to around $109,925 in 2025, reflecting changes in demand, location, experience, and the wider economy. For a detailed analysis of Principal Scientist, Medicinal Chemistry salary trends, .

Average Annual Salary of Principal Scientist, Medicinal Chemistry Over Time

2022
$???
2023
$111,606
2024
$110,376
2025
$109,925
2026
$???
2027
$???
Year Average Annual Salary
2022
View More
2023 $111,606
2024 $110,376
2025 $109,925
2026
View More
2027
View More

Most common benefits for Principal Scientist, Medicinal Chemistry

Social Security
401(k)
Disability
Healthcare
Pension
Time Off (days)
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Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

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