As of February 01, 2026, the average annual salary for Machine Learning Engineer in Saint Louis, MO is $106,220, equivalent to $51 per hour, $2,043 weekly, or $8,852 monthly. These figures, sourced from Salary.com’s real-time job posting scans, highlight competitive earning potential for Machine Learning Engineer in cities like Santa Clara, San Jose, and Fremont.

Annually Salaries for Machine Learning Engineer in Saint Louis, MO vary widely, spanning from $90,063 to $123,484. Most professionals fall between the 25th percentile ($97,763) and 75th percentile ($115,257), while top earners (90th percentile) make $123,484 per year. This $17,494 pay gap underscores opportunities for salary growth through certifications, specialized skills like Analysis or Software Development, or targeting high-paying regions like District of Columbia or California.

Location and experience significantly influence earnings. For example, Saint Louis Machine Learning Engineer often earn 1.7% lower than national averages. However, Saint Louis currently ranks 497 statewide for Machine Learning Engineer job salary. Professionals are advised to focus on high-growth sectors like to offset market challenges.

Based on HR-reported data: a national average with a geographic differential
Machine Learning Engineer Salaries by Percentile
Percentile Salary Location Last Updated
10th Percentile Machine Learning Engineer Salary $90,063 Saint Louis, MO February 01, 2026
25th Percentile Machine Learning Engineer Salary $97,763 Saint Louis, MO February 01, 2026
50th Percentile Machine Learning Engineer Salary $106,220 Saint Louis, MO February 01, 2026
75th Percentile Machine Learning Engineer Salary $115,257 Saint Louis, MO February 01, 2026
90th Percentile Machine Learning Engineer Salary $123,484 Saint Louis, MO February 01, 2026
25% $97,763 10% $90,063 90% $123,484 75% $115,257 $106,220 50%(Median) Didn’t find job title? Click
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Machine Learning Engineer - Infra

F. Hoffmann-La Roche AG - California, MO

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What is a Machine Learning Engineer ?

Machine learning (ML) is the scientific study of algorithms and statistical models that computer systems use to effectively perform a specific task without using explicit instructions, relying on patterns and inference instead. It is seen as a subset of artificial intelligence. Machine learning algorithms build a mathematical model of sample data, known as "training data", in order to make predictions or decisions without being explicitly programmed to perform the task.:2 Machine learning algorithms are used in a wide variety of applications, such as email filtering, and computer vision, where...

Source: Wikipedia (as of 04/25/2019). Read more from Wikipedia

See user submitted job responsibilities for Machine Learning Engineer.

Job Openings for Machine Learning Engineer in Saint Louis, MO

Career Path for this job

  1. Down a level:

    Software Engineer II

    2 - 4 years experience
    Bachelor's Degree

  2. This Job:

    Machine Learning Engineer

    4 - 7 years experience
    Bachelor's Degree

  3. Up a level:

    Software Engineer IV

    7 + years experience
    Bachelor's Degree

Understand the total compensation opportunity for a Machine Learning Engineer, base salary plus other pay elements

Average Base Salary

Core compensation

 
 
 
97763
115257
106220

Average Total Cash Compensation

Includes base and annual incentives

 
 
 
106106
130165
117550
These charts show the average base salary (core compensation), as well as the average total cash compensation for the job of Machine Learning Engineer in Saint Louis, MO. The base salary for Machine Learning Engineer ranges from $97,763 to $115,257 with the average base salary of $106,220. The total cash compensation, which includes base, and annual incentives, can vary anywhere from $106,106 to $130,165 with the average total cash compensation of $117,550.

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For a real-time salary target, tell us more about your role in the four categories below.

97763
115257

 

About Saint Louis, Missouri    St. Louis (/seɪnt ˈluːɪs/) is an independent city and major inland port in the U.S. state of Missouri. It is situated along the western bank of the Mi....More

Saint Louis, Missouri  area prices were up 0.7% from a year ago

Machine Learning Engineer Salary in popular cities: Kansas CitySpringfieldIndependence

Jobs with a similar salary range to Machine Learning Engineer : Computer Vision Researcher, Software Administrator, Software Developers