Lead Clinical Data Manager Salary in the United States

How much does a Lead Clinical Data Manager make in the United States?

As of June 01, 2026, the average salary for a Lead Clinical Data Manager in the United States is $141,780 per year, which breaks down to an hourly rate of $68.

However, a Lead Clinical Data Manager's salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $177,429
  • Majority Range (25th-75th percentile): $130,106 to $160,440
  • Entry-Level (10th percentile): $119,477
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View as table View as graph 25% $130,106 10% $119,477 90% $177,429 75% $160,440 $141,780 50%(Median) Didn’t find job title? Click

Lead Clinical Data Manager Salaries by Percentile

Annual
Salary		 Monthly
Pay		 Weekly
Pay		 Hourly
Wage
75th Percentile $160,440 $13,370 $3,085 $77
Average $141,780 $11,815 $2,727 $68
25th Percentile $130,106 $10,842 $2,502 $63
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Key Factors That Influence Lead Clinical Data Manager Salaries

A Lead Clinical Data Manager's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location, education and company size can directly affect your earning potential.

How Experience Level Affects Lead Clinical Data Manager Salaries?

Experience is a primary driver of a Lead Clinical Data Manager's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

  • Entry-Level (less than 1 year): $136,185
  • Early Career (1-2 years): $136,692
  • Mid-Level (2-4 years): $140,407
  • Senior-Level (5-8 years): $146,445
  • Expert (over 8 years): $147,268
Levels Salary
Entry Level Lead Clinical Data Manager$136,185
Intermediate Level Lead Clinical Data Manager$136,692
Senior Level Lead Clinical Data Manager$140,407
Specialist Level Lead Clinical Data Manager$146,445
Expert Level Lead Clinical Data Manager$147,268
$136,185 0 yr
$136,692 < 2 yrs
$140,407 2-4 yrs
$146,445 5-8 yrs
$147,268 > 8 yrs
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What Am I Worth?

How Do Lead Clinical Data Manager Salaries Vary from State to State?

Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Lead Clinical Data Managers. For example, consider the average annual salaries in these key locations:

  • District of Columbia: $156,979.
  • California: $156,383.
  • Massachusetts: $154,299.

Top Paying Cities for Lead Clinical Data Managers

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $178,827
  • San Francisco: $176,869
  • Oakland: $173,142

What Skills Can Increase a Lead Clinical Data Manager's Salary?

Demanded Skills for the Role:

  • Project Management (Mentioned in 2.56% Job Postings): Project management is the application of processes, methods, skills, knowledge and experience to achieve specific project objectives according to the project acceptance criteria within agreed parameters. Project management has final deliverables that are constrained to a finite timescale and budget.
  • Database Design (Mentioned in 2.07% Job Postings): Overlap to row 560
  • Data Collection (Mentioned in 1.59% Job Postings): Data collection is the process of gathering and measuring information on targeted variables in an established system, which then enables one to answer relevant questions and evaluate outcomes. Data collection is a component of research in all fields of study including physical and social sciences, humanities, and business. While methods vary by discipline, the emphasis on ensuring accurate and honest collection remains the same. The goal for all data collection is to capture quality evidence that allows analysis to lead to the formulation of convincing and credible answers to the questions that have been posed.
See More Skills
Skills Demand Percentage
Project Management 2.56%
Database Design 2.07%
Data Collection 1.59%
What skills can make your compensation higher?
Mastering certain specialized skills can lead to a significant increase in pay. Here are examples of skills and the potential impact they can have on a Lead Clinical Data Manager's salary.
  • Biostatistics: Can increase your salary by up to 5%.
  • Drug Development: Can increase your salary by up to 5%.
  • Programming: Can increase your salary by up to 4%.
Skill Salary Salary % Increase
Biostatistics
 $148,869
5%
Drug Development
 $148,869
5%
Programming
 $147,451
4%
Planning
 $147,451
4%
SAS
 $147,451
4%
Innovation
 $147,451
4%
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How Education impacts a Lead Clinical Data Manager's Salary?

Your level of education can impact your salary potential. While many Lead Clinical Data Managers enter the field with a Master's Degree or MBA degree, higher education can lead to more specialized and higher-paying roles.

According to our 100% employer-reported salary data, the median salary for a Lead Clinical Data Manager with a Master's Degree or MBA is between $119,184 and $125,657).

Lead Clinical Data Manager Salaries by Degree Level

Typical Education for Lead Clinical Data Manager
Degree Level % of user with this level of education
No Diploma 7.3%
High School 7.3%
Associates 2.9%
Bachelors 49.6%
Masters 32.8%
Doctorate 7.3%
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Lead Clinical Data Manager Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Lead Clinical Data Manager's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

  • Hourly
  • Monthly
  • Weekly
  • Yearly
  • Table View
Last Updated on June 01, 2026
$130,106
Average $141,780/year
$160,440
$10,842
Average $11,815/month
$13,370
$2,502
Average $2,727/week
$3,085
$63
Average $68/hour
$77
Annual Salary Monthly Pay Weekly Pay Hourly Wage
75th Percentile $160,440 $13,370 $3,085 $77
Average $141,780 $11,815 $2,727 $68
25th Percentile $130,106 $10,842 $2,502 $63

Salaries of jobs related to Lead Clinical Data Manager

Salary Trends for Lead Clinical Data Manager

Salaries for a Lead Clinical Data Manager can change over time, reflecting shifts in market demand and the overall economy. The median salary decreased from $140,514 in 2023 to around $132,411 in 2025, reflecting changes in demand, location, experience, and the wider economy. For a detailed analysis of Lead Clinical Data Manager salary trends, .

Average Annual Salary of Lead Clinical Data Manager Over Time

2022
$???
2023
$140,514
2024
$135,026
2025
$132,411
2026
$???
2027
$???
Year Average Annual Salary
2022
View More
2023 $140,514
2024 $135,026
2025 $132,411
2026
View More
2027
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Most common benefits for Lead Clinical Data Manager

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401(k)
Disability
Healthcare
Pension
Time Off (days)
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Common company salaries for Lead Clinical Data Manager

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Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

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