The average salary for a Registered Nurse (RN) in Appleton, WI is between $63,952 and $113,614 as of October 01, 2026. Salary ranges can vary widely depending on the actual Registered Nurse (RN) position you are looking for. With more online, real-time compensation data than any other website, Salary.com helps you determine your exact pay target.
About Appleton, Wisconsin Appleton is a city in Outagamie (mostly), Calumet, and Winnebago counties in the U.S. state of Wisconsin. One of the Fox Cities, it is situated on the....More
Appleton, Wisconsin area prices were up 1.3% from a year ago View the Cost of Living in Appleton, Wisconsin
Core compensation
A registered nurse cares for patients in various settings including hospitals, nursing homes, clinics, schools, and physician's offices. Nurses work together with other medical professionals to administer treatments and to monitor and record the condition of patients as they are treated. Nurses are also educators, helping patients and their families understand the treatments and medications they are receiving. Nurses may have specialized skills and training required to care for different populations of patients for example pediatrics, critical care, cardiology, or surgery.