In certain states with a high demand for specialized neonatal care, NICU nurses can indeed earn six-figure salaries, especially with considerable experience or additional certifications. While the national average salary for a NICU nurse is approximately $80,000 annually, some regions such as California, New York, and Massachusetts offer higher compensation that can surpass $100,000 per year. Factors contributing to these higher salaries include the cost of living, the level of hospital funding, and the complexity of cases handled. Additionally, NICU nurses working in urban or high-demand areas, or those with advanced skills and years of experience, are more likely to reach or exceed a six-figure income. Overall, while not typical across all regions, earning a six-figure salary as a NICU nurse is achievable in specific circumstances and locations.