As of October 01, 2026, the average salary for a Clinical Information Systems Senior Manager in the United States is $156,000 per year, which breaks down to an hourly rate of $75.
However, a Clinical Information Systems Senior Manager's salary can vary significantly. Here’s a look at the typical salary range:
Clinical Information Systems Senior Manager Salaries by Percentile
| Annual Salary |
Monthly Pay |
Weekly Pay |
Hourly Wage |
|
|---|---|---|---|---|
| 75th Percentile | $164,600 | $13,717 | $3,165 | $79 |
| Average | $156,000 | $13,000 | $3,000 | $75 |
| 25th Percentile | $144,200 | $12,017 | $2,773 | $69 |
A Clinical Information Systems Senior Manager's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.
Experience is a primary driver of a Clinical Information Systems Senior Manager's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:
| Job Role | Years of Experience | Average Salary |
|---|---|---|
| Health Informatics Specialist III | 4-7 years | $111,367 |
| Clinical Information Systems Manager | 7+ years | $139,150 |
| Clinical Information Systems Senior Manager | 7+ years | $155,918 |
| Clinical Information Systems Director | 7+ years | $172,572 |
| Chief Nursing Information Officer (CNIO) | 7+ years | $223,960 |
Clinical Information Systems Senior Manager salary potential scales significantly with company size. Data shows that Enterprise companies (5,000+ employees) pay the highest average salary at around $175,226. While startup companies pay approximate $148,909.
| Company Size | Employees | Average Salary |
|---|---|---|
| Startup | 1~50 | $148,909 |
| Growth Stage | 51~500 | $157,306 |
| Established | 501~5000 | $169,334 |
| Enterprise | 5000+ | $175,226 |
Understanding how a Clinical Information Systems Senior Manager's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.
| Annual Salary | Monthly Pay | Weekly Pay | Hourly Wage | |
|---|---|---|---|---|
| 75th Percentile | $164,600 | $13,717 | $3,165 | $79 |
| Average | $156,000 | $13,000 | $3,000 | $75 |
| 25th Percentile | $144,200 | $12,017 | $2,773 | $69 |
Next Role
Advancement
For a Clinical Information Systems Senior Manager, the most direct path to higher earnings is advancing to the Clinical Information Systems Director role. This promotion typically comes with a significant pay increase, bringing the average annual salary to $172,600 - a projected growth of 11% over your current level.
Salaries for a Clinical Information Systems Senior Manager can change over time, reflecting shifts in market demand and the overall economy. The median salary decreased from $142,866 in 2023 to around $138,859 in 2025, reflecting changes in demand, location, experience, and the wider economy. For a detailed analysis of Clinical Information Systems Senior Manager salary trends, .
| Year | Average Annual Salary |
|---|---|
| 2022 | View More |
| 2023 | $142,866 |
| 2024 | $141,005 |
| 2025 | $138,859 |
| 2026 |
View More
|
| 2027 |
View More
|
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The Pharmaceuticals industry offers the highest average compensation for Clinical Information Systems Senior Manager roles, with salaries approximately 20% above the market median.
Many MIS graduates work in roles such as IT managers, systems analysts, or database administrators, where salaries are competitive. For instance, a Clinical Information Systems Senior Manager can expect a salary ranging from $132,100 to $168,600, with a midpoint of $148,600. This reflects the potential for high earnings in the field.
The salary for a Clinical Information Systems Senior Manager in the US ranges from a minimum of $132,100 to a maximum of $168,600, with a median salary of $148,600. This reflects the compensation for professionals in this role, indicating a competitive salary structure within the field.
The highest salary for a Clinical Information Systems Senior Manager is $168,600 per year. In the United States, Senior Managers typically earn between $132,100 and $168,600, with a mid-range salary of $148,600.
The highest paying clinical job is often considered to be an Anesthesiologist, earning around $339,470. However, a Clinical Information Systems Senior Manager also commands a competitive salary, with a range from $132,100 to $168,600, and a midpoint of $148,600, reflecting the importance of technology in healthcare management.
As of now, the salary for a Clinical Information Systems Senior Manager in the US ranges from $132,100 to $168,600 annually, with a midpoint of $148,600. This translates to approximately $63.49 to $81.05 per hour, or $2,538 to $3,138 per week. The monthly earnings range from $11,008 to $14,550.
A senior manager generally holds a higher position than a lead. The title lead often refers to a lower-level supervisory role, while senior manager indicates a more advanced role with greater responsibilities. In terms of compensation, a Clinical Information Systems Senior Manager earns between $132,100 and $168,600, reflecting their higher level of responsibility and expertise.
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