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Clinical Information Systems Senior Manager Salary in the United States

How much does a Clinical Information Systems Senior Manager make in the United States?

As of August 01, 2026, the average salary for a Clinical Information Systems Senior Manager in the United States is $155,900 per year, which breaks down to an hourly rate of $75.

However, a Clinical Information Systems Senior Manager's salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $172,521
  • Majority Range (25th-75th percentile): $144,200 to $164,600
  • Entry-Level (10th percentile): $133,548
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View as table View as graph 25% $144,200 10% $133,548 90% $172,521 75% $164,600 $155,900 50%(Median) Didn’t find job title? Click

Clinical Information Systems Senior Manager Salaries by Percentile

Annual
Salary
Monthly
Pay
Weekly
Pay
Hourly
Wage
75th Percentile $164,600 $13,717 $3,165 $79
Average $155,900 $12,992 $2,998 $75
25th Percentile $144,200 $12,017 $2,773 $69
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Key Factors That Influence Clinical Information Systems Senior Manager Salaries

A Clinical Information Systems Senior Manager's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location, and company size can directly affect your earning potential.

How Experience Level Affects Clinical Information Systems Senior Manager Salaries?

Experience is a primary driver of a Clinical Information Systems Senior Manager's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

  • Health Informatics Specialist III (4-7 years): $111,340
  • Clinical Information Systems Manager (7+ years): $139,105
  • Clinical Information Systems Senior Manager (7+ years): $155,895
  • Clinical Information Systems Director (7+ years): $172,587
  • Chief Nursing Information Officer (CNIO) (7+ years): $223,953
Job Role Years of Experience Average Salary
Health Informatics Specialist III4-7 years$111,340
Clinical Information Systems Manager7+ years$139,105
Clinical Information Systems Senior Manager7+ years$155,895
Clinical Information Systems Director7+ years$172,587
Chief Nursing Information Officer (CNIO)7+ years$223,953
$111,340 Health In...
$139,105 Clinical ...
$155,895 Clinical ...
$172,587 Clinical ...
$223,953 Chief Nur...
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Top Paying Cities for Clinical Information Systems Senior Managers

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $196,700
  • San Francisco: $194,500
  • Oakland: $190,400

Clinical Information Systems Senior Manager Salary by Company Size: Startups vs. Enterprise

Clinical Information Systems Senior Manager salary potential scales significantly with company size. Data shows that Enterprise companies (5,000+ employees) pay the highest average salary at around $175,424. While startup companies pay approximate $148,999.

Clinical Information Systems Senior Manager Salary by Company Size

Company Size Employees Average Salary
Startup1~50$148,999
Growth Stage51~500$157,415
Established501~5000$169,555
Enterprise5000+$175,424

Clinical Information Systems Senior Manager Salary by Industry: Top Paying Sectors

For Clinical Information Systems Senior Manager roles, the industry you choose can affect earning potential by as much as 40% (the gap between the highest and lowest paying industries). Data shows that the Pharmaceuticals and Healthcare sectors offer the strongest compensation, at 20% above the average. In contrast, Clinical Information Systems Senior Manager positions in Edu., Gov't. & Nonprofit or Biotechnology typically offer lower base pay, as these industries often view Clinical Information Systems Senior Manager as a support function rather than a direct revenue driver.

The top paying industries for a Clinical Information Systems Senior Manager

Industry Sector Average Annual Salary Average Hourly Rate Pay vs.Avg
Pharmaceuticals$187,080$90.020%
Healthcare$171,490$82.010%

Clinical Information Systems Senior Manager Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Clinical Information Systems Senior Manager's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

Last Updated on August 01, 2026

Clinical Information Systems Senior Manager Salary Growth & Career Path

For a Clinical Information Systems Senior Manager, the most direct path to higher earnings is advancing to the Clinical Information Systems Director role. This promotion typically comes with a significant pay increase, bringing the average annual salary to $172,600 - a projected growth of 11% over your current level.

Salary Trends for Clinical Information Systems Senior Manager

Salaries for a Clinical Information Systems Senior Manager can change over time, reflecting shifts in market demand and the overall economy. The median salary decreased from $142,866 in 2023 to around $138,859 in 2025, reflecting changes in demand, location, experience, and the wider economy. For a detailed analysis of Clinical Information Systems Senior Manager salary trends, .

Average Annual Salary of Clinical Information Systems Senior Manager Over Time

2022
$???
2023
$142,866
2024
$141,005
2025
$138,859
2026
$???
2027
$???
Year Average Annual Salary
2022
View More
2023 $142,866
2024 $141,005
2025 $138,859
2026
View More
2027
View More

Most common benefits for Clinical Information Systems Senior Manager

Social Security
401(k)
Disability
Healthcare
Pension
Time Off (days)
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Common company salaries for Clinical Information Systems Senior Manager

Here are companies hiring for Clinical Information Systems Senior Manager and their salaries, click below for more details.

Find Your Next Clinical Information Systems Senior Manager Job

Ready to take the next step in your career? Browse thousands of current Clinical Information Systems Senior Manager job openings on our job board. Use the search bar below to find your perfect match.

United States
  • M/I Homes

    Columbus, OH

    M/I Homes | Columbus, OH

    Job Description. Job Description. M/I Homes has been building new homes of outstanding quality and superior design for 50 years. Founded in 1976 by Irving ... more

    5 Days Ago

  • S R INTERNATIONAL INC

    Columbus, OH

    S R INTERNATIONAL INC | Columbus, OH

    Job Description. Job Description. LOOKING FOR ONLY CURRENT OHIO RESIDENTS. In Person Interviews. Hybrid role in Columbus - Needs to be able to come in pers... more

    5 Days Ago

  • Siemens

    Columbus, OH

    Siemens | Columbus, OH

    Siemens - - Responsibilities: Install conduit, wire, cable, and devices including panels, sensors, and components for a range of systems, ensuring their pr... more

    5 Days Ago

  • Ohio State University

    Columbus, OH

    Ohio State University | Columbus, OH

    Facilities Building Systems Techn. Under the supervision of a senior technician or supervisor, performs intermediate level tasks that ensure a safe and com... more

    5 Days Ago

  • Ohio State University

    Columbus, OH

    Ohio State University | Columbus, OH

    Facilities Building Systems Technician. Under supervision of Senior/Lead technician or Supervisor the Facilities Building HVAC Systems Technician performs ... more

    6 Days Ago

  • Siemens

    Columbus, OH

    Siemens | Columbus, OH

    Security Systems Technician. Security System Technicians play a crucial role in ensuring the safety and efficiency of our Smart Buildings. You will be resp... more

    6 Days Ago

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FAQ about Clinical Information Systems Senior Manager

1. What industry pays the highest salary for Clinical Information Systems Senior Manager?

The Pharmaceuticals industry offers the highest average compensation for Clinical Information Systems Senior Manager roles, with salaries approximately 20% above the market median.

2. Is information systems a high paying degree?

Many MIS graduates work in roles such as IT managers, systems analysts, or database administrators, where salaries are competitive. For instance, a Clinical Information Systems Senior Manager can expect a salary ranging from $132,100 to $168,600, with a midpoint of $148,600. This reflects the potential for high earnings in the field.

3. What is the salary of information systems manager in the US?

The salary for a Clinical Information Systems Senior Manager in the US ranges from a minimum of $132,100 to a maximum of $168,600, with a median salary of $148,600. This reflects the compensation for professionals in this role, indicating a competitive salary structure within the field.

4. What is the highest salary of a senior manager?

The highest salary for a Clinical Information Systems Senior Manager is $168,600 per year. In the United States, Senior Managers typically earn between $132,100 and $168,600, with a mid-range salary of $148,600.

5. What is the highest paying clinical job?

The highest paying clinical job is often considered to be an Anesthesiologist, earning around $339,470. However, a Clinical Information Systems Senior Manager also commands a competitive salary, with a range from $132,100 to $168,600, and a midpoint of $148,600, reflecting the importance of technology in healthcare management.

6. How much do senior managers make in the US?

As of now, the salary for a Clinical Information Systems Senior Manager in the US ranges from $132,100 to $168,600 annually, with a midpoint of $148,600. This translates to approximately $63.49 to $81.05 per hour, or $2,538 to $3,138 per week. The monthly earnings range from $11,008 to $14,550.

7. Is a senior manager higher than a lead?

A senior manager generally holds a higher position than a lead. The title lead often refers to a lower-level supervisory role, while senior manager indicates a more advanced role with greater responsibilities. In terms of compensation, a Clinical Information Systems Senior Manager earns between $132,100 and $168,600, reflecting their higher level of responsibility and expertise.

Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

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