Research Associare/Associate Scientist, AAV Vector Production

Adverum is looking for a highly motivated AAV Vector Production Research Associate/Associate Scientist to join our Research team at our Redwood City, CA office. The successful candidate will play a critical role in planning and executing the production of AAV viral vectors and their application to Adverum’s gene therapy pipeline of products. The incumbent will be responsible for manufacturing, purification and chracterization of research grade recombinant Adeno Associated Virus (rAAV).

This is a contract opportunity - 6 month to start.

• Plan and execute the production of rAAV vectors in shake flasks and bench top bioreactors to expand Adverum’s gene therapy product pipeline.
• Maintain accurate experimental records with little supervision.
• Analyze, interpret and present data within functional group environment.
• Perform molecular biology and analytical assays.
• Draft, edit and finalize technical documents following templates with minimal supervision.
• Perform literature searches to gain ideas for incorporation into process optimization.
• Collaborate with other departments (Pre-Clinical, Process Development, Analytical Development etc) to achieve shared objectives.
• Ensure safe workplace in compliance with the company and EHS rules and regulations.

• PhD’s/Master’s/Bachelor’s degree in Cell Biology, Molecular Biology, Biology, Virology, Biochemistry, Biophysics, chemical/biochemical engineering or related field and 2 years relevant biotechnology industry experience.
• Knowledge of mammalian cell culture and AAV Production in an industry setting.
• Hands-on experience working with mammalian suspension cell cultures and aseptic techniques.
• Hands-on experience with density gradient purification.
• Hands-on experience with column chromatography purification is desirable but not required.
• Hands-on experience with different molecular biology tools used to characterize AAV vectors (such as ddPCR, qPCR, alkaline gel, Western blot).
• Experience drafting technical protocols/reports.
• Familiarity with bench-scale bioreactor operations is desirable but not required.
• Excellent organizational and collaborative skills, with the ability to design and troubleshoot experiments with minimal supervision or as part of a group.
• Highly motivated team player with an ability to be productive and a willingness to learn in a fluid, fast-paced and environment is essential.

About Us

Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.

At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self.  We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation