Senior Scientist I

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

Key Responsibilities

• Responsible for developing, optimizing & executing new analytical methods & techniques to characterize complex proteins/glycoproteins, antigens & novel protein-based therapeutics.
• Work within multi-disciplinary project teams & act as a lead analytical & biophysical resource to guide development & advance pipeline.
• Resolve key project challenges by effectively utilizing available analytical tools, information & technical expertise.
• Develop, optimize & execute new analytical methods & techniques to characterize complex proteins/glycoproteins, antigens & novel protein-based therapeutics.
• Strategically advance scientific expertise within the Analytics group by conceiving & executing novel scientific research & development efforts to address project challenges & provide novel insights.
• Demonstrate leadership by advising & sharing knowledge & expert opinions with peers & senior management.
• Contribute to research that leads to peer-reviewed publications, reports & external presentations.
• Employ experience in protein analytical & biophysical characterization to discern protein critical quality attributes (physiochemical properties, post-translational modifications) & better understand protein structure-function relationships.
• Work in cross-functional teams with scientists across functions & therapeutic areas (Virology, Immunology, Oncology & Neuroscience) to discover & develop next generation biologics through interrogation & engineering of protein attributes across both targets and therapeutic molecules.
• Responsible for utilizing verbal & written skills & the ability to clearly present scientific concepts & results for functional scientific & non-scientific leaders.
• Employ experience with in-depth protein analytical characterization using a variety of techniques such as LC-MS/MS, SE-HPLC, CE, CD, NMR, TEM, SE-HPLC-MALS, DLS, iCIEF.
• Employ experience utilizing various software such as Thermo Xcalibur, BSI PEAKS, PMI Byologic, Wyatt Astra, Wyatt Dynamics, MS Word, MS Excel, MS Ppt, PRISM, & ImageJ.
• Responsible for demonstrating proficiency with various chromatographic techniques, capillary electrophoresis methodologies & in-depth biophysical characterization.
• Responsible for preparation and characterization of disease-relevant proteins in defined morphological states. Employ experience in guiding recombinant protein expression & purification.
• Employ experience with protein labeling & conjugation, as well as protein formulation & remediation. Prepare written documentation, reports & presentations of work & strategies.
• Work on the selection of targets or variants for therapeutic development & include the design, engineering & characterization of resulting therapeutics & their mechanisms of action.
• Employ experience with routine mass spectrometry workflows, including intact & subunit analysis.
• Responsible for project driven initiatives that will require scientific exploration & experimentation as well as close collaboration with scientists across the organization.
• Responsible for new technology development by expanding analytical expertise & custom assays, project leadership, hypothesis-driven experimentation, orientated towards discovering & developing novel therapeutics.
  
  
  

Qualifications

Must possess a Bachelors or foreign equivalent degree in Chemistry, Chemical Biology, Chemical Engineering, Biochemistry, Biophysics, or a highly related field of study plus 10 years of related progressive experience.

In the alternative, employer will accept a Masters degree or foreign equivalent in Chemistry, Chemical Biology, Chemical Engineering, Biochemistry, Biophysics, or a highly related field of study plus 8 years of related progressive experience, or employer will accept a Ph.D. degree or foreign equivalent in Chemistry, Chemical Biology, Chemical Engineering, Biochemistry, Biophysics, or a highly related field of study plus an academic or industrial background.

Required

Must possess expertise/knowledge sufficient to adequately perform the duties of the job being offered. Expertise/knowledge may be gained through employment experience or education. Such expertise/knowledge cannot be quantified by time. Required expertise/knowledge includes:

(i) developing, optimizing and executing new analytical methods and techniques to characterize complex proteins/glycoproteins, antigens and novel protein-based therapeutics;

(ii) in-depth protein analytical characterization using a variety of techniques including: LCMS/MS, SE-HPLC, CE, CD, NMR, TEM, SE-HPLC-MALS, DLS, iCIEF;

(iii) software such as Thermo Xcalibur, BSI PEAKS, PMI Byologic, Wyatt Astra, Wyatt Dynamics, MS Word, MS Excel, MS Ppt, PRISM, & ImageJ;

(iv) various chromatographic techniques, capillary electrophoresis methodologies and in-depth biophysical characterization;

(v) routine mass spectrometry workflows, including intact and subunit analysis; &

(vi) expanding analytical expertise and custom assays, project leadership, hypothesis-driven experimentation, orientated towards discovering & developing novel therapeutics.

Employer will accept any suitable combination of education, training or experience.

Apply online at https://careers.abbvie.com/en. Refer to Req ID: REF24400D.

Additional Information

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term and long-term incentive programs.

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.