What are the responsibilities and job description for the Clinical Variant Analyst position at Broad Institute?
The Broad Institute Clinical Research Sequencing Platform (CRSP) is a CLIA licensed, CAP accredited clinical laboratory providing physicians and physician-researchers with high quality molecular tests. We are searching for a variant curation scientist to support the CRSP laboratory’s current clinical tests including germline whole genome and somatic whole exome.
This position will be involved in genomic case analysis and variant classification and work in close collaboration with other members of the CRSP and Translational Analysis Group (TAG) teams, which include analysts, clinicians/providers, computational biologists, software engineers, senior laboratory personnel and project managers.
T he candidate should have a strong background in genetics or a related discipline, have fluency in human disease genetics, have good attention to detail and be able to adapt quickly and be part of a cross-functional team in a rapidly changing environment.
A variant analyst will interact with both germline and somatic data in support of clinical research, clinical trials, and clinical diagnostics.
This is an opportunity to play a role in large-scale genomics, informatics, and disease genetics as well as contribute to the development and implementation of transformative new clinical tests that could impact patients on an individual basis.
Primary Responsibilities:
Directly analyze exome and genome data for identification of disease-causing variants, using existing and newly-developed analysis tools.
Assess, maintain and improve variant annotation and filtration capabilities.
Present results and progress at regular team and other Broad Institute meetings.
Support data quality review and release of data
Support development and validation of new clinical assays
Involvement in abstract, figure, and manuscript preparation and submission, and presentations at local or national professional conferences.
Requirements
Master’s Degree in Genetic Counseling/Human Genetics/Genomics from an ABGC accredited Program OR other relevant discipline or equivalent experience required. ASCP accreditation a plus.
Experience in genomic case analysis and variant classification for germline disease using ACMG/AMP guidelines; somatic cancer testing experience a plus
Deep understanding of human genetics and next-generation DNA sequencing
Experience in cloud-based computing a plus. Some experience in Python, R, and Unix would be advantageous.
Demonstrated attention to detail and analytical skills
Excellent communication skills
Excellent organization and time management skills
Highly collaborative and able to work well in a team.
Desire to contribute to a fast paced, exciting work environment.
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All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Requests for exemption for medical or sincerely held religious beliefs will be considered.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.