Associate Principal Scientist/Senior Scientist, Analytical Development

Philadelphia, PA

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, visit www.cabalettabio.com and follow us on LinkedIn and X (Twitter).

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work®

About the Position:

Reporting to Director, Analytical Development, We are seeking a talented and experienced Associate Principal Scientist/Senior Scientist with expertise in development and qualification of phase-appropriate analytical test methods for cell therapy products. The successful candidate will contribute to the development of advanced analytics to characterize quality attributes of CAART and CARTA cell therapies which leads to better treatment efficacy and safety.  The individual will also play a crucial role in advancing our analytical capabilities to support the development of novel CAR- and CAAR-T cell therapy products, lentiviral vector, new gene transfer/gene editing methodologies and potential clinical programs.

Responsibilities:

• Lead the design, development, optimization, and qualification of analytical methods or other advanced technologies, as required to evaluate safety, purity, identity, potency of lentiviral vectors and cell therapy products.
• Provide technical expertise and guidance on analytical techniques, instrumentation, and data analysis methodologies.
• Analyze and interpret experimental data, troubleshoot technical challenges, and propose solutions to drive continuous improvement in analytical methods.
• Execute quality control assays to analyze lentiviral vectors, and cell products manufactured by external partners.
• Develop new analytical tests to assess advanced gene transfer and gene editing modalities.
• Assist to author analytical development report, assay qualification report and other technical documents for technical correctness and regulatory compliance.
• Participate in technical troubleshooting and problem investigation.
• Prepare, evaluate, and present data internally to cross functional teams.
• Generate and communicate research findings through presentations, scientific publications, and contributions to regulatory documents.
• Provide technical guidance, mentorship, and training to junior scientists and research associates within the team.

Qualifications:

• MS with a minimum of 3-5 years ’industry experience or PhD degree with a minimum of 2-4 years of industry experience in a relevant scientific discipline (e.g., cell biology, immunology, biochemistry, biotechnology) in analytical development for cell therapy or biologics.
• Proven expertise in developing and qualifying analytical assays for the characterization of cell-based products, including flow cytometry, ELISA/MSD, qPCR/dPCR/ddPCR, cell-based assays, potency assays and other advanced technologies.
• Strong understanding of regulatory requirements (e.g., FDA, EMA, ICH guidelines) governing analytical method qualification/validation, data integrity, and GMP compliance in the biopharmaceutical industry.
• Excellent analytical and problem-solving skills, with the ability to analyze complex data sets, identify trends, and propose data-driven solutions.
• Effective communication and interpersonal skills, with the ability to collaborate effectively in a multidisciplinary team environment and present technical information clearly and concisely.
• Proven track record of successful project management, including the ability to prioritize tasks, manage timelines, and deliver high-quality results in a fast-paced, dynamic environment.
• Strong leadership qualities with a passion for mentoring and developing junior team members.
• Strong team orientation and passion for continuous self-development.
• Experience in the biotech industry or in a startup industrial setting is preferred.

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit  https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.