Data Scientist I

At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai’s human health care (hhc) mission. We’re a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer’s disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you. Eisai has been dedicated for decades to the pursuit of novel therapeutics to improve the lives of people suffering from dementia and their families. Recognizing the potential for human genetics, data sciences and precision chemistry to disrupt the drug discovery paradigm, Eisai launched the Eisai Center for Genetics Guided Dementia Discovery (G2D2) in 2019 to accelerate the discovery of innovative therapeutics. G2D2 is a unique drug discovery organization driven by a diverse group of passionate, dedicated and collaborative scientists committed to one goal: delivering breakthroughs for patients and their families. All Eisai employees, as part of the company’s human health care (hhc) mission, spend at least 1% of their working time with patients and families to ensure that the innovation we drive is based on an understanding of their real needs. At G2D2, we focus on how human genetics and other human biology data may identify and validate therapeutic targets with increased likelihood of success in clinical trials, and utilize this data to guides selection of the best approaches to design new therapeutics and the selection of strategies to deliver these therapeutics to the right patient at the right time. Recognizing the obvious alignment between human genetics and nucleic acid modalities, our precision chemistry strategy is to directly validate human biology hypotheses by utilizing our unique RNA targeting therapeutic platform. G2D2’s expertise in harnessing molecular complexity (stereochemistry and topology) to successfully discover and develop natural product based therapeutics has been applied to create an evolving unique nucleic acid immunotherapeutic platform that is being employed globally in multiple clinical and pre-clinical programs at Eisai. G2D2’s cutting-edge 50,000-square-foot facility is strategically located in Cambridge, MA, to accelerate collaborations with leading research institutes in this world-class biotech hub. Our facility has been designed around an open-lab concept, enabling scientists with multi-disciplinary backgrounds to work together in a single integrated lab space. Our labs include state-of-the-art capabilities that support the variety of disciplines located at the site, including medicinal and process chemistry, in-vitro and in-vivo biology, microscopy, DMPK, drug safety, chemical and structural biology, automation and screening, and more. G2D2 is home to Eisai’s US discovery data science teams, and which support global discovery efforts using cutting edge analytical approaches. G2D2 is also home to other global Eisai functions, including global health, DMPK, Safety, IP, oncology, thus providing a rich environment for cross-functional interaction. Our office is designed to foster an atmosphere of mission-driven and collaborative science, using new collaboration tools and technologies, and is being optimized to support a hybrid work environment. At Eisai, we highly value both internal and external collaboration and pursue flexible research models with a range of external scientific partners to accelerate delivery of innovative medicines. To this end, the G2D2 facility includes the Eisai Innovation Center Biolabs, which provides space and infrastructure to start-up/spin-out companies conducting high-risk but potentially transformative research that can impact the discovery of breakthrough therapeutics. More information about G2D2 is provided here (http://eisai.mediaroom.com/2018-06-12-Eisai-Inc-to-Launch-Center-for-Genetics-Guided-Dementia-Discovery-in-Cambridge-Massachusetts) and here (https://us.eisai.com/research/g2d2), and about Eisai's strategy and pipeline are provided here (https://www.eisai.com/index.html). Job Summary: As a bioinformatics data analyst within the Discovery Computational Biology team, the candidate will be responsible for a variety of bioinformatic drug discovery activities, including the elucidation of biological changes associated with potential toxicology, drug target proposals, and creating biomarker strategies. The focus of this role will be on utilizing extensive internal and external expression data to support our early and late-stage drug discovery efforts, while providing training and leadership to bioinformatics team members and drug discovery biologists alike. The Data Scientist Iwill join an existing (and evolving) data science group at Eisai-G2D2 and will encounter a corporate culture that is very motivated to apply computational biology and other data-driven approaches to R&D at every level of the organization. Given the expanding scope of the group’s operations, the successful candidate will have the opportunity to help shape the direction and focus of our bioinformatics team as we support global expression analysis within Eisai. Primary Responsibilities: Develop new capabilities to leverage single cell RNASeq and spatial transcriptomics Design, implement, and apply statistical, network, and machine learning techniques to analyze and integrate large, complex datasets (e.g., RNA-seq, scRNAseq, proteomics, metabolomics, etc.) Work closely with interdisciplinary teams of wet and dry lab collaborators towards drug discovery Translate in vitro/vivo findings to bolster our understanding of human disease pathology, patient quality of life, and potential disease subtypes leading to patient stratification Clearly communicate key findings through interactive data visualizations and presentations Work cross-functionally among R&D teams, workstreams, and programs to provide statistical support and bioinformatics expertise across the neurology portfolio Work independently and as part of a team, with a willingness to learn new or unfamiliar types of analysis approaches as needed Mentor/coach team members and peers in technical and scientific aspects Qualifications/Skills: PhD with 1 – 5 years of industry or relevant experience with strong expertise in data science and machine learning required Knowledge of programming languages, i.e. R, Python, and Unix / high-performance computing environment, including software development practices such as version control (git, SVN, etc.) Experience with distributed computing, database (e.g., SQL) or relational databases (e.g., PostgreSQL), and Amazon Web Services is preferred Extensive expertise analyzing publicly available as well as internally generated transcriptomic (bulk RNA-seq, scRNA-seq) and proteomic data for drug discovery and development processes Statistical knowledge of probability distributions, sampling techniques, causal inference and other statistical concepts Experience with drug discovery in neurology, oncology and/or immunology is preferred Strong communications skills, including data visualization experience (RShiny, Spotfire, Tableau) Eager to work collaboratively in a team and to both give and receive feedback to support professional development for self and others The ability to thrive in a flexible, goal-oriented environment is required #LI-MG1 IND123 Eisai is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, Eisai prohibits discrimination against persons because of disability, including disabled veterans. Eisai Inc. participates in E-Verify. E-Verify is an Internet based system operated by the Department of Homeland Security in partnership with the Social Security Administration that allows participating employers to electronically verify the employment eligibility of all new hires in the United States. Please click on the following link for more information: Right To Work E-Verify Participation At Eisai Inc., human health care (hhc) is our goal. We give our first thoughts to patients and their families, and helping to increase the benefits health care provides. As the U.S. pharmaceutical subsidiary of Tokyo-based Eisai Co., Ltd., we have a passionate commitment to patient care that is the driving force behind our efforts to discover and develop innovative therapies to help address unmet medical needs. Eisai is a fully integrated pharmaceutical business that operates in two global business groups: oncology and neurology (dementia-related diseases and neurodegenerative diseases). Our U.S. headquarters, commercial and clinical development organizations are located in New Jersey; our discovery labs are in Massachusetts and Pennsylvania; and our global demand chain organization resides in Maryland and North Carolina. To learn more about Eisai Inc., please visit us at www.eisai.com/US and follow us on Twitter and LinkedIn. All data that is entered should be in the correct case, please refrain from using all caps. For a better user experience, we recommend using the latest version of Chrome.