Principal Associate Scientist, Pharmaceutical Sciences (Formulation)

Why join us?

FogPharma is a clinical-stage biopharmaceutical company that seamlessly integrates breakthroughs in bench science and data science to create transformative precision therapeutics for patients suffering from devastating and often fatal diseases such as cancer. FogPharma’s discovery engine creates Helicon™ therapeutics, which are a new generation of ultra-diverse, highly tunable peptide drugs capable of modulating virtually any protein implicated in disease. Our robust and wholly owned pipeline of programs is currently focused on cancer targets that are intractable to small molecules and biotherapeutics.

The company’s lead program, FOG-001, is a long sought-after blocker of β-catenin:TCF interactions that is currently being evaluated in a Phase 1/2 clinical trial in patients with Wnt/β-catenin signaling pathway-activated solid tumors, including colorectal cancer. FogPharma has raised more than $350 million to date from top investors and is led by an experienced team of industry experts. FogPharma is headquartered in Cambridge, MA.

What’s the opportunity?

In this role, you will partner with scientists across the organization to discover and develop the best Helicon^TM peptides and tailor them to fit patients’ needs. We are looking for an enthusiastic and innovative scientist to join a multidisciplinary team and help us discover and develop novel inhibitors of undruggable disease targets. Your role will report to the Senior Formulation Scientist and will be to support drug product development at FogPharma. This will require both hands-on and strategic approaches, leveraging internal and external capabilities with high flexibility. Ideal candidates will be experienced, energetic, and passionate, with a broad knowledge of parenteral formulation development. This position is primarily lab-based, and you will be a primary data generator with opportunities to influence and guide the formulation strategy for our investigative drugs.  

• Support drug product development activities at FogPharma.
• Partner with early discovery through CMC to develop and implement fit-for-purpose formulations for our Helicon^TM
• Leverage internal and external capabilities to advance our programs.
• Lead by example and take a hands-on approach to solving our most pressing challenges.

What you’ll need to be successful:

• MS with 7 years or BS with 10 years of industry experience in Formulation Development. 
• Experience developing parenteral formulations to support preclinical research, candidate selection, and IND-enabling studies. Experience with clinical drug product development and manufacturing is a plus. 
• Experience developing fit-for-purpose analytical methods to support formulation development, especially U/HPLC-based methods. 
• Excellent communication, organization, strategic, and cross-functional team skills.
• Formulation and analytical experience with parenteral small molecules and/or biologics is preferred.
• Experience managing external vendors for formulation and analytical development is a plus.
• Experience with Quality Assurance, Quality systems, and GMP production is a plus.
• Able to work on-site and attend in-person meetings (Fog employees are required to be fully vaccinated to attend in-person work-related activities. Reasonable Accommodations will be made for individuals with a sincerely held religious belief or disability who are not vaccinated)

Core Values

FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
• Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.