Analytical Scientist/Lab Head

Cambridge, MA-based H3 Biomedicine (H3B) is a leading company in cancer genomics driven drug discovery, delivering on the promise of precision medicine. The company was launched in 2011 with an unprecedented $200 million in initial funding from Eisai, plus a continued ongoing commitment to fund H3B’s robust discovery pipeline and clinical programs. Now with three clinical stage anti-cancer molecules in active development, H3B is able to uniquely leverage distinct insights from cancer genomics and real-life patient data to advance its projects to clinical proof of concept and beyond. H3B embraces a novel business model in which it collaborates with Eisai, a leading global pharmaceutical company, to create a prolific drug discovery engine and partnership platform.

We are looking for an analytical chemist with a passion for working with colleagues toward H3 Biomedicine’s vision. A key element of her/him is a strong interest in data and purification techniques. As a key member of a project, she/he is expected to work independently and demonstrate creativity within a multi-disciplinary environment.

Key Responsibilities
Collaborate with Medicinal Chemistry to support discovery activities:

• Develop analytical methods for the analysis of chiral and achiral molecules including by HPLC, GC and LCMS, conduct analytical testing and stability studies of research compounds to support formulation, synthesis development in Early Development
• Develop and implement platform analytical methods to support medicinal chemistry and provide local analytical support as needed
• Oversee the chiral and achiral chromatographic separation and purification of research compounds with medicinal chemistry
• Responsible for the proper maintenance and operation of the analytical equipment in the laboratories including HPLC, LCMS and Preparative Chromatography systems.
• Responsible for oversight of analytical work performed at CROs.
• Promote compliance on Health, Safety and Environment in the analytical laboratories

Qualifications

• PhD in Pharmaceutical Analytical Chemistry or related sciences, or a BS with a minimum of 5 years of experience within the pharmaceutical/biotech industry.
• Experience managing a small group of direct reports or teams
• Expertise with the chromatographic separation of chiral and achiral molecules for the development and validation of analytical methods needed for the analysis and stability studies of compounds in pre-development and early CMC development
• Expertise with the study and identification of chemical process impurities and degradation products
• Computer literacy with proficiency in Microsoft Office software, electronic notebook documentation and LIMS
• Experience in preparing analytical reports as source documents for pre-development and early development
• Excellent communication abilities along with experience with good documentation practices.
• Experience working with cross-functional teams
• Track record of successfully developing chromatographic methods for the determination of both chiral and achiral compounds and low-level related substances

H3 Biomedicine is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, H3 Biomedicine prohibits discrimination against persons because of disability, including disabled veterans.

H3 Biomedicine Inc. participates in E-Verify. E-Verify is an Internet based system operated by the Department of Homeland Security in partnership with the Social Security Administration that allows participating employers to electronically verify the employment eligibility of all new hires in the United States.