Associate Scientist, Formulation

At Intellia, we are revolutionizing medicine by harnessing the power of genome editing to develop potential cures. We bring new hope for people living with conditions including cancer, genetic disorders, viral infections, inflammatory disorders and many more. Intellia Therapeutics, Inc. Associate Scientist, Formulation Cambridge, MA   Duties: Routinely prepare lipid nanoparticle-based and conventional formulations at varying scales and characterize formulations using advanced analytical methods. Work closely with the Senior Scientist on lipid nanoparticle (LNP) design and analytical method development and perform analyses of protein, nucleic acid, and LNP samples and drug products. Optimize existing analytical methods and formulation processes and generate standard operating procedures (SOPs) and test method documents. Provide high quality data to drive decision making in the non-viral delivery formulation team. Conduct experiments, independently and in collaboration with colleagues in support of project goals. Design, plan and establish experimental work-flows and acquire and analyze respective data to inform decision making. Trouble-shoot experiments and instrumentation to reach desired goals. Communicate research and development findings with internal and external partners. Operate and maintain multiple laboratory instruments. Assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering and receiving of lab supplies.   Requirements: Requires a Master’s degree in Pharmaceutical Sciences, Chemical Engineering, or a directly related field plus two (2) years of biotech or pharmaceutical experience.   Must have one (1) year of experience in each of the following (experience may be gained concurrently): -         Experience with novel delivery systems including lipid nanoparticles -         Experience with preparation of LNP-based formulations at different scales sufficient to support in vivo studies in rodent and higher species -         Experience in characterizing and developing novel drug delivery systems for nucleic acids, proteins or small molecules -         Experience with large (>2000 nt) and smaller (100 nt) RNA constructs -         Experience with analytical techniques relevant to i) characterizing nanoparticle properties (particle size, polydispersity, pKa, encapsulation efficiency) by DLS, SEC-MALS/AF4-MALS, UV-Vis and fluorescence assays ii) lipid content/purity by HPLC/UPLC and iii) RNA cargo characteristics (content/purity) by fluorescent assays, HPLC methods, Capillary Electrophoresis methods) -         Troubleshooting, documenting, and transferring analytical methods for particle size, nucleic acid quantification, nucleic acid encapsulation and lipid quantification.   40 hours per week. Send resume to: Shaun.Vigeant@Intelliatx.com ref. P13. What Intellia Stands For: At Intellia, our mission is to develop potentially curative genome editing treatments that can positively transform the lives of people living with severe and life-threating diseases. We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are: - One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us – trusting and counting on every single one of us. - Explore because we seek new ways to tackle disease. Explore with unbounded minds…free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways. - Disrupt by thinking courageously…and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts…with that breed of skepticism that shows you have better solutions. - Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards…even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.   POSITION: Full-Time, Exempt EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.