What are the responsibilities and job description for the Principal Scientist/Associate Director: Protein Sciences position at Paragon Therapeutics, Inc.?
Join the Paragon team to help drive the protein engineering of our programs from ideation to IND. Work with Research Leadership and partner CROs on design and implementation of Paragon’s biotherapeutics pipeline. Lead the Protein Sciences function of biotherapeutics programs in a fast-paced early biotech environment and manage the biologics drug discovery workflows including but not limited to antigen design, antibody discovery campaigns, and protein production and characterization.
Key Responsibilities:
- Work with partner CROs on design and implementation of binding protein discovery campaigns using in vivo and in vitro approaches
- Collaborate with pharmacology lead to design antibody hit screening funnels
- Oversee hit-to-lead biotherapeutic protein developability assessments, and devise lead optimization strategies to identify drug candidates
- Lead biotherapeutics discovery projects
Requirements:
- PhD in biochemistry, immunology, cell biology, or related field
- 8 years of experience in biologics drug discovery, with at least 5 years in biotech or pharma
- Deep experience and understanding of biotherapeutics discovery workflows including antigen design and generation, binding protein discovery and optimization, and developability assessments. Experience with structural analysis tools is a plus
- Demonstrated experience in optimizing therapeutic antibodies using a combination of manufacturability engineering, humanization, and affinity maturation in an industry setting
- Expertise in antibody or protein library generation and display technologies using phage, mammalian, or yeast display approaches
- Experience in working with multispecific antibody formats
- Program leadership experience in biotech or pharma
- Ability to manage multiple projects with CRO partners
- Independent self-starter with strong organizational and communication skills
If you are interested in this career, please send a cover letter and your resume to [ Email address blocked ] - Click here to apply to Principal Scientist/Associate Director: Protein Sciences.
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