Molecular Imaging Scientist

Position Overview:

Molecular and/or cellular biologist with interest in advancing the field of high-plex spatial transcriptome functional genomics applied to the molecular dissection of disease and disease therapeutics.  The role will be within the Translational Sciences Single Cell and Functional Genomics group focused on a diverse therapeutic portfolio within rare disease, neurobiology, gene therapy, oncology and immunology. The Translational Sciences Group in Sanofi strives to generate scientific knowledge that translates into transformative therapies for patients with unmet medical needs.  Translational Sciences is building a world-class high-content imaging and spatial profiling team that is passionate to contribute to the discovery and development of novel therapeutics for patients.  The Translational Sciences group is seeking highly motivated genomics scientists to join the multidisciplinary team to apply spatial transcriptome technologies to multiple disease areas.  As a result, the successful candidate would contribute to various drug discovery and development projects for a number of indications of interest to Sanofi.  The successful candidate will play a key role in sustaining and expanding the capabilities of our spatial technology platform, with a deep understanding of existing and new technologies to drive and impact the emerging field of high-plex spatial biology.  A key contributor to multidisciplinary teams developing spatial biology workflows and analytics, with end-to-end systems integration.  You will plan, initiate, and execute scientific research and define development strategies in collaboration with the research staff and the ability to analyze complex datasets, and strong oral and written communication skills.  The successful candidate will have the training, knowledge and expertise in the application of advanced approaches on a diverse set of biological samples to generate datasets to develop actionable hypotheses.  The successful candidate would have the ability to learn and acquire new techniques and methodologies.  The selected candidate is expected to contribute to developing analytical strategies for the identification of novel therapeutic targets, the discovery of predictive biomarkers for patients’ stratification, and analysis of molecular data to define disease and therapeutic molecular mechanisms.  This exciting role will afford talented molecular biology or genomics scientists the opportunity to translate their data-generation and analytical abilities into novel actionable hypotheses.

Key Responsibilities:

• Member of multidisciplinary team to apply high-plex spatial functional genomics platforms and technologies to a variety of disease and therapeutic tissue types.

• Nanostring GeoMx DSP/NGS platform proficiency, NGS knowledge and wet-bench skill to sustain and expand GeoMx assays with NGS Readout.

• Provide molecular histology and imaging laboratory expertise.

• Produce, QC, and interpret high-plex data sets.

• Communicate and collaborate with therapeutic collaborators.

• Collaborate with other groups in Translational Sciences and Therapeutic Area partners and help the group champion projects from discovery to early clinical development.

• Prepare publications, research and clinical/regulatory documentation in accordance with Sanofi quality standards.

Essential Qualifications:

• Bachelor’s degree with 6 years of relevant research experience OR Master’s degree with 3 years of relevant research experience OR a PhD in biochemistry, molecular biology, or genomics.

• Track record of independent research and development in genomics (e.g. scRNA-seq), imaging techniques, and/or spatial technologies.

• Ability to analyze large complex, spatial genomics data sets with a mind toward multi-omic integrative analysis.

• Experience with automated molecular histology and imaging platforms, multiplex immunohistochemistry and/or in situ hybridization assays with the ability to largely work independently in the lab.

• Whole slide image capture across multiple scanning platforms, and image analysis using HALO and/or Visiopharm platforms, with the ability to interpret data to define results and next steps.

• Team player able to collaborate with multiple project teams.

Preferred Qualifications:

• Machine learning/AI segmentation of whole tissues.

• Digital pathology, image and data management.

• Understanding of tissue pathology.

• Protein/nucleic single and multiplex assay optimization/validation.

• Experience in NGS data processing and proficiency in data analysis in R and/or python.

• Excellent written and oral communication skills.

• Excellent interpersonal and team skills.

• Established publication record.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.  Sanofi achieves its mission, in part, by offering rewarding career opportunities which inspire employee growth and development.  Our 6 Recruitment Principles clarify our commitment to you and your role in driving your career.

Our people are responsible for managing their career

Sanofi posts all non-executive opportunities for our people

We give priority to internal candidates

Managers provide constructive feedback to all internal interviewed candidates

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Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.