Research Scientist

Title: Research Scientist

Location: Cambridge, MA

Start date: ASAP

Responsibilities:

• The Research Scientist will join the Early Drug Discovery group in Cambridge, MA and aide in the advancement of early-stage therapeutic targets.
• The position will utilize genome engineering, mechanistic biology, assay development, and other cutting-edge technologies to validate tumor intrinsic targets and support drug discovery pipeline.
• The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment and aid the advancement of the next wave of targets into preclinical drug development.
• The candidate will be expected to effectively collaborate with colleagues across discovery oncology including the exploratory pharmacology, drug discovery and translational research groups.
• The position requires the ability to design, iterate, and lead several key project initiatives and demonstrate critical thinking to challenge self and others.
• The successful candidate will demonstrate clear and professional verbal and written communication skills and will be capable of communicating these results across multidisciplinary teams.

Requirements:

• A B.S. with a minimum of 7 years, an M.S. with a minimum of 5 years, or a PhD with a minimum of 3 years of academic/industrial experience and demonstrated expertise in cancer biology and genetics, oncogenic signaling or DNA damage response pathways
• Demonstrated independence in experimental design, execution, data analysis, and troubleshooting are required.
• Strong scientific and hands-on experience using a wide range of cellular and molecular biology techniques, including tissue culture, flow cytometry, western blotting, Immunoprecipitation, development of reporter assays, MSD, ELISA, use of genetic perturbation techniques (eg shRNA,siRNA CRISPR-mediated genome editing), qRT-PCR, cell proliferation assays, lentivirus generation and transduction are required.
• Experience in forward and reverse genetic screening followed by target validation studies to elucidate mechanistic biology and oncogenic SAR is strongly preferred.
• Proficiency in utilizing software such as Graph Pad, FlowJo, Microsoft office etc. for data analysis and figure generation is required.
• Ability to lead, design, and execute on project initiatives and operates to a High Standard. Attention to detail with excellent organizational and record keeping skills is a requirement.
• Excellent interpersonal skills with the ability to interact effectively with people, internally and externally, is required.
• This position is located in Cambridge, MA.