Scientist

Scientist

TechnoFix is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Benefits We Offer:

• Medical, Dental & Vision Coverage for Employees
• Paid Time Off and Paid Holidays
• Facilitate 401K
• Employee Referral Bonus

Overview

TechnoFix is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientist to join our vibrant team at the National Institutes of Health (NIH), Vaccine Research Center (VRC), Virology Core Section (VCS).

Technical Requirements:

• Design of experiments to utilizing rodent and non-human primate models to study vivo pharmacokinetic (PK) studies of monoclonal antibodies.
• Design and execution of experimental approaches to characterize monoclonal antibodies, including binding (ELISA and related techniques), measures of antibody affinity (biolayer interferometry or surface plasmon resonance approaches), and functional assays (including antibody-neutralization studies). 
• Conduct animal studies to evaluate the immunogenicity of vaccines (including intramuscular, subcutaneous, intraperitoneal, and intravenous injection, sample collection and processing). 
• Discover and characterize monoclonal antibodies. 
• Monoclonal antibody production and purification from mammalian cells. 
• Viral pseudotype or infectious virus production and characterization for use in antibody characterization studies. 
• Perform maintenance for multiple cell culture lines used in laboratory experiments.
• Perform flow cytometry experiments.
• Manage colonies of mouse strains for studying antibody PK and VRC vaccine development programs.
• Represent the Virology Core at internal virtual product development meetings to provide subject matter expertise on antibody development and PK. 
• Provide expert PK analysis in support of VRC regulatory submissions. 
• Participate in the management and safe operation of the Virology Core laboratory including the maintenance of accurate records, inventories, shipping of biological materials, ordering, and training.

Specific Qualifications:  

• Ph.D. in a relevant biomedical field with (3) years of experience of laboratory experience. 
• Demonstrable expertise in laboratory studies involving antibody or biological pharmacokinetics. 
• Expertise in the design of experiments utilizing rodent and non-human primate models to study vivo pharmacokinetic (PK) studies of monoclonal antibodies. 
• Demonstrable experience with small animal models. 
• Expertise in the design and execution of experimental approaches to characterize monoclonal antibodies, including binding (ELISA and related techniques), measures of antibody affinity (biolayer interferometry or surface plasmon resonance approaches), and functional assays (including antibody-neutralization studies).
• Expertise in monoclonal antibody production and purification of mammalian cells. 
• Detailed knowledge of pharmacokinetics, PK modeling, and the use of related data analysis tools (Phoenix WinNonlin, R, NONMEM, or other pharmacokinetic, modeling and data visualization software). 
• Willingness to work with infectious pathogens using BSL-2 containment.
• Exceptional organizational skills. 
• Exceptional collaboration, coordination, and communication skills.
• A commitment to teamwork in a fast-paced, highly collaborative laboratory environment.
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The diversity of TechnoFix’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment. We will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, or status concerning public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need accommodation as part of the employment process please contact: hr@technofoixitsolutions.com

Disclaimer: The above description is meant to illustrate the general nature of work and the level of effort being performed by individuals assigned to this position or job description. This is not restricted to a complete list of all required skills, responsibilities, duties, and/or assignments. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.