Scientist, Immuno-Oncology (Flow Cytometry)

 Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area—near Pasadena—and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics, antibodies and cytokines with improved function, with the goal of improving patient outcomes and quality of life. We have an excellent opportunity for a Scientist, Immuno-Oncology to join our team.

Our protein engineering capabilities and the modular nature of our XmAb technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are advancing a deep clinical pipeline of novel drug candidates, including eight bispecific antibodies and two engineered cytokines, and more programs are expected to start clinical testing in 2022. We also leverage our many XmAb technologies by collaborating with leading global biopharmaceutical companies, including Genentech and Janssen Biotech, among others, and including our partnerships, 20 XmAb drug candidates are advancing through clinical development. Three XmAb medicines, to treat patients with a range of serious illnesses, such as aggressive lymphoma, rare blood disorders and COVID-19, are now marketed worldwide by partners.

Our employees are the most important factor in our success, and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees’ value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.

The Discovery Biology & Pharmacology department plays an important role in discovery projects. It supports screening of therapeutic proteins for biological activity, development of assays to understand mechanism of action, and provides flow cytometry support to in vivo studies. The ideal candidate is highly motivated, able to work in a fast-paced environment, and passionate about developing immunomodulatory therapeutics for the treatment of cancer and autoimmune diseases. She/he will contribute towards identification of therapeutic candidates using cellular and immunological methods. This is an exciting opportunity to impact the next wave of drug development candidates to enter our pipeline.

Candidates should have a demonstrated record of technical proficiency and scientific creativity, and an ability to work effectively with other talented scientists. Experience presenting information to groups of individuals highly desirable!

Job Duties:  

• Develop and conduct immunological and cellular bioassays to support development of clinical candidates. 
• Support translational and animal model studies for testing the efficacy and safety of therapeutic proteins. 
• Document experimental protocols, design and details in an electronic laboratory notebook 
• Analyze and interpret experimental data, and prepare presentations and technical reports 
• Communicate data to team members in a timely manner and present data to senior management in departmental and companywide meetings. 
• Follow all laboratory safety guidelines, practices and protocols. 

Qualifications:  

• Minimum of PhD; post-doctoral or industry experience is a plus 
• Technical expertise in multicolor flow cytometry 
• Experience in human immunology and designing experiments with human PBMCs 
• Familiarity with antigen-specific immune responses, cytokine biology and tumor immunology 
• Extensive experience in culturing of primary cells from mouse or human tissues 
• Expertise with software such as BD FACSDiva, FlowJo, Prism and Excel for data and statistical analysis.

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. 

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice. 

Physical, Mental and Environment Demands:

The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.

The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply.

Specific mental demands for the position are listed above under requirements.  In addition, mental demands for this position include:

• Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources.
• Ability to work and sustain attention with distractions and/or interruptions.
• Ability to interact appropriately with a variety of individuals including vendors, customers and clients.
• Ability to maintain regular attendance and be punctual.
• Ability to understand, remember and follow verbal and written instructions.

Occasional travel may be required, including travel between Xencor’s Monrovia and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.

Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact HR@xencor.com.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.

Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.

Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.