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As of August 01, 2026, the average salary for a Register Nurse in South Carolina is $69,387 per year, which breaks down to an hourly rate of $33.
However, a Register Nurse's salary can vary significantly. Here’s a look at the typical salary range:
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Register Nurse Salaries by Percentile
| Annual Salary |
Monthly Pay |
Weekly Pay |
Hourly Wage |
|
| 75th Percentile | $77,137 | $6,428 | $1,483 | $37 |
| Average | $69,387 | $5,782 | $1,334 | $33 |
| 25th Percentile | $61,489 | $5,124 | $1,182 | $30 |
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A Register Nurse's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.
Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Register Nurses. For example, consider the average annual salaries in these key locations:
Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:
For Register Nurse roles, the industry you choose can affect earning potential by as much as 40% (the gap between the highest and lowest paying industries). Data shows that the Energy & Utilities and Biotechnology sectors offer the strongest compensation, at 20% above the average. In contrast, Register Nurse positions in Software & Networking or MFG Nondurable typically offer lower base pay, as these industries often view Register Nurse as a support function rather than a direct revenue driver.
| Industry Sector | Average Annual Salary | Average Hourly Rate | Pay vs.Avg |
|---|---|---|---|
| Energy & Utilities | $83,265 | $40.0 | 20% |
| Biotechnology | $79,796 | $38.0 | 15% |
| Insurance | $76,326 | $37.0 | 10% |
| Healthcare | $72,857 | $35.0 | 5% |
Understanding how a Register Nurse's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.
| Annual Salary | Monthly Pay | Weekly Pay | Hourly Wage | |
|---|---|---|---|---|
| 75th Percentile | $77,137 | $6,428 | $1,483 | $37 |
| Average | $69,387 | $5,782 | $1,334 | $33 |
| 25th Percentile | $61,489 | $5,124 | $1,182 | $30 |
Ready to take the next step in your career? Browse thousands of current Register Nurse job openings on our job board. Use the search bar below to find your perfect match.
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Kaiser Permanente | HAPPY VALLEY, OR
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EUDOWOOD, MD
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WESTWOOD, MO
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LAKE CHESTERFIELD, MO
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MANCHESTER, MO
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MARATHON CITY, WI
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