As of August 01, 2026, the average salary for a Clinical Data Manager II in the United States is $145,280 per year, which breaks down to an hourly rate of $70.
However, a Clinical Data Manager II's salary can vary significantly. Here’s a look at the typical salary range:
Compensation Planning
Develop a Job Description
Pay Equity
2026 Compensation Trend
AI-Powered HR
Smart Recruiting
A Clinical Data Manager II's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location, education and company size can directly affect your earning potential.
Experience is a primary driver of a Clinical Data Manager II's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here’s how the average salary grows at different career stages:
| Levels | Salary |
|---|---|
| Entry Level Clinical Data Manager II | $139,549 |
| Intermediate Level Clinical Data Manager II | $140,068 |
| Senior Level Clinical Data Manager II | $143,874 |
| Specialist Level Clinical Data Manager II | $150,061 |
| Expert Level Clinical Data Manager II | $150,904 |
What Am I Worth?
Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Clinical Data Manager IIs. For example, consider the average annual salaries in these key locations:
Demanded Skills for the Role:
| Skills | Demand Percentage |
|---|---|
| Project Management | 2.56% |
| Database Design | 2.07% |
| Data Collection | 1.59% |
| Skill | Salary | Salary % Increase |
|---|---|---|
|
Biostatistics
|
$152,544 |
5%
|
|
Drug Development
|
$152,544 |
5%
|
|
Programming
|
$151,091 |
4%
|
|
Planning
|
$151,091 |
4%
|
|
SAS
|
$151,091 |
4%
|
|
Innovation
|
$151,091 |
4%
|
For Clinical Data Manager II roles, the industry you choose can affect earning potential by as much as 40% (the gap between the highest and lowest paying industries). Data shows that the Biotechnology and Edu., Gov't. & Nonprofit sectors offer the strongest compensation, at 20% above the average. In contrast, Clinical Data Manager positions in Business Services or Healthcare typically offer lower base pay, as these industries often view Clinical Data Manager II as a support function rather than a direct revenue driver.
| Industry Sector | Average Annual Salary | Average Hourly Rate | Pay vs.Avg |
|---|---|---|---|
| Biotechnology | $174,336 | $84.0 | 20% |
| Edu., Gov't. & Nonprofit | $159,808 | $77.0 | 10% |
Your level of education can impact your salary potential. While many Clinical Data Manager IIs enter the field with a Master's Degree or MBA degree, higher education can lead to more specialized and higher-paying roles.
According to our 100% employer-reported salary data, the median salary for a Clinical Data Manager II with a Master's Degree or MBA is between $119,184 and $125,657).
Clinical Data Manager II Salaries by Degree Level
| Degree Level | % of user with this level of education |
|---|---|
| No Diploma | 7.3% |
| High School | 7.3% |
| Associates | 2.9% |
| Bachelors | 49.6% |
| Masters | 32.8% |
| Doctorate | 7.3% |
Understanding how a Clinical Data Manager II's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.
Last Updated on August 01, 2026Salaries for a Clinical Data Manager II can change over time, reflecting shifts in market demand and the overall economy. The median salary decreased from $143,957 in 2023 to around $135,656 in 2025, reflecting changes in demand, location, experience, and the wider economy. For a detailed analysis of Clinical Data Manager II salary trends, .
| Year | Average Annual Salary |
|---|---|
| 2022 |
View More
|
| 2023 | $143,957 |
| 2024 | $138,335 |
| 2025 | $135,656 |
| 2026 |
View More
|
| 2027 |
View More
|
If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution.
Compensation PlanningHere are companies hiring for Clinical Data Manager II and their salaries, click below for more details.
Ready to take the next step in your career? Browse thousands of current Clinical Data Manager II job openings on our job board. Use the search bar below to find your perfect match.
Get a Salary Increase
Analyze the market and your qualifications to negotiate your salary with confidence.
Search Job Openings
Search thousands of open positions to find your next opportunity.
Adjust Employee Salary
Individualize employee pay based on unique job requirements and personal qualifications.
Price My Industry Jobs
Get the latest market price for benchmark jobs and jobs in your industry.
The Biotechnology industry offers the highest average compensation for Clinical Data Manager II roles, with salaries approximately 20% above the market median.
Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.
We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)
With the most extensive online, real-time compensation data available, Salary.com helps you pinpoint your exact pay target.
Salary.com's CompAnalyst platform offers:
