Clinical Data Manager II Salary in the United States

How much does a Clinical Data Manager II make in the United States?

As of April 01, 2026, the average salary for a Clinical Data Manager II in the United States is $145,229 per year, which breaks down to an hourly rate of $70.

However, a Clinical Data Manager II's salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $181,789
  • Majority Range (25th-75th percentile): $133,269 to $164,366
  • Entry-Level (10th percentile): $122,380
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View as table View as graph 25% $133,269 10% $122,380 90% $181,789 75% $164,366 $145,229 50%(Median) Didn’t find job title? Click

Clinical Data Manager II Salaries by Percentile

Annual
Salary		 Monthly
Pay		 Weekly
Pay		 Hourly
Wage
75th Percentile $164,366 $13,697 $3,161 $79
Average $145,229 $12,102 $2,793 $70
25th Percentile $133,269 $11,106 $2,563 $64
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Key Factors That Influence Clinical Data Manager II Salaries

A Clinical Data Manager II's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location, education and company size can directly affect your earning potential.

How Experience Level Affects Clinical Data Manager II Salaries?

Experience is a primary driver of a Clinical Data Manager II's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

  • Entry-Level (less than 1 year): $139,497
  • Early Career (1-2 years): $140,016
  • Mid-Level (2-4 years): $143,822
  • Senior-Level (5-8 years): $150,013
  • Expert (over 8 years): $150,857
Levels Salary
Entry Level Clinical Data Manager II$139,497
Intermediate Level Clinical Data Manager II$140,016
Senior Level Clinical Data Manager II$143,822
Specialist Level Clinical Data Manager II$150,013
Expert Level Clinical Data Manager II$150,857
$139,497 0 yr
$140,016 < 2 yrs
$143,822 2-4 yrs
$150,013 5-8 yrs
$150,857 > 8 yrs
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What Am I Worth?

How Do Clinical Data Manager II Salaries Vary from State to State?

Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Clinical Data Manager IIs. For example, consider the average annual salaries in these key locations:

  • District of Columbia: $160,798.
  • California: $160,188.
  • Massachusetts: $158,053.

Top Paying Cities for Clinical Data Manager IIs

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $183,177
  • San Francisco: $181,376
  • Oakland: $177,354

What Skills Can Increase a Clinical Data Manager II's Salary?

Demanded Skills for the Role:

  • Project Management (Mentioned in 2.56% Job Postings): Project management is the application of processes, methods, skills, knowledge and experience to achieve specific project objectives according to the project acceptance criteria within agreed parameters. Project management has final deliverables that are constrained to a finite timescale and budget.
  • Database Design (Mentioned in 2.07% Job Postings): Overlap to row 560
  • Data Collection (Mentioned in 1.59% Job Postings): Data collection is the process of gathering and measuring information on targeted variables in an established system, which then enables one to answer relevant questions and evaluate outcomes. Data collection is a component of research in all fields of study including physical and social sciences, humanities, and business. While methods vary by discipline, the emphasis on ensuring accurate and honest collection remains the same. The goal for all data collection is to capture quality evidence that allows analysis to lead to the formulation of convincing and credible answers to the questions that have been posed.
See More Skills
Skills Demand Percentage
Project Management 2.56%
Database Design 2.07%
Data Collection 1.59%
What skills can make your compensation higher?
Mastering certain specialized skills can lead to a significant increase in pay. Here are examples of skills and the potential impact they can have on a Clinical Data Manager II's salary.
  • Biostatistics: Can increase your salary by up to 5%.
  • Drug Development: Can increase your salary by up to 5%.
  • Programming: Can increase your salary by up to 4%.
Skill Salary Salary % Increase
Biostatistics
 $152,490
5%
Drug Development
 $152,490
5%
Programming
 $151,038
4%
Planning
 $151,038
4%
SAS
 $151,038
4%
Innovation
 $151,038
4%
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How Education impacts a Clinical Data Manager II's Salary?

Your level of education can impact your salary potential. While many Clinical Data Manager IIs enter the field with a Master's Degree or MBA degree, higher education can lead to more specialized and higher-paying roles.

According to our 100% employer-reported salary data, the median salary for a Clinical Data Manager II with a Master's Degree or MBA is between $119,184 and $125,657).

Clinical Data Manager II Salaries by Degree Level

Typical Education for Clinical Data Manager II
Degree Level % of user with this level of education
No Diploma 7.3%
High School 7.3%
Associates 2.9%
Bachelors 49.6%
Masters 32.8%
Doctorate 7.3%
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Clinical Data Manager II Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Clinical Data Manager II's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

  • Hourly
  • Monthly
  • Weekly
  • Yearly
  • Table View
Last Updated on April 01, 2026
$133,269
Average $145,229/year
$164,366
$11,106
Average $12,102/month
$13,697
$2,563
Average $2,793/week
$3,161
$64
Average $70/hour
$79
Annual Salary Monthly Pay Weekly Pay Hourly Wage
75th Percentile $164,366 $13,697 $3,161 $79
Average $145,229 $12,102 $2,793 $70
25th Percentile $133,269 $11,106 $2,563 $64

Salaries of jobs related to Clinical Data Manager II

Salary Trends for Clinical Data Manager II

Salaries for a Clinical Data Manager II can change over time, reflecting shifts in market demand and the overall economy. The median salary decreased from $143,957 in 2023 to around $135,656 in 2025, reflecting changes in demand, location, experience, and the wider economy. For a detailed analysis of Clinical Data Manager II salary trends, .

Average Annual Salary of Clinical Data Manager II Over Time

2022
$???
2023
$143,957
2024
$138,335
2025
$135,656
2026
$???
2027
$???
Year Average Annual Salary
2022
View More
2023 $143,957
2024 $138,335
2025 $135,656
2026
View More
2027
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Most common benefits for Clinical Data Manager II

Social Security
401(k)
Disability
Healthcare
Pension
Time Off (days)
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Common company salaries for Clinical Data Manager II

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Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

With the most extensive online, real-time compensation data available, Salary.com helps you pinpoint your exact pay target.

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