As of August 01, 2026, the average annual salary for Internal Medicine Nurse in Missouri is $91,051, equivalent to $44 per hour, $1,751 weekly, or $7,588 monthly. These figures, sourced from Salary.com’s real-time job posting scans, highlight competitive earning potential for Internal Medicine Nurse in cities like San Jose, Santa Clara, and San Francisco.

Annually Salaries for Internal Medicine Nurse in Missouri vary widely, spanning from $79,561 to $107,142. Most professionals fall between the 25th percentile ($85,036) and 75th percentile ($99,474), while top earners (90th percentile) make $107,142 per year. This $14,438 pay gap underscores opportunities for salary growth through certifications, specialized skills like Planning or Nursing Process, or targeting high-paying regions like District of Columbia or California.

Location and experience significantly influence earnings. For example, Missouri Internal Medicine Nurse often earn 5.0% lower than national averages due to demand from Fortune 56 companies. However, Missouri currently ranks 37 nationwide for Internal Medicine Nurse job salary. Professionals are advised to focus on high-growth sectors like to offset market challenges.

Based on HR-reported data: a national average with a geographic differential
Internal Medicine Nurse Salaries by Percentile
Percentile Salary Location Last Updated
10th Percentile Internal Medicine Nurse Salary $79,561 MO August 01, 2026
25th Percentile Internal Medicine Nurse Salary $85,036 MO August 01, 2026
50th Percentile Internal Medicine Nurse Salary $91,051 MO August 01, 2026
75th Percentile Internal Medicine Nurse Salary $99,474 MO August 01, 2026
90th Percentile Internal Medicine Nurse Salary $107,142 MO August 01, 2026
25% $85,036 10% $79,561 90% $107,142 75% $99,474 $91,051 50%(Median) Didn’t find job title? Click
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What is An Internal Medicine Nurse ?

The salary for an Internal Medicine Nurse varies based on factors such as experience, location, and the healthcare facility. On average, these professionals earn between $70,000 and $100,000 annually. Entry-level positions may start around $60,000, while those with advanced certifications or extensive experience can exceed $100,000. Geographic location plays a significant role, with urban areas typically offering higher salaries due to the cost of living. Additionally, specialized skills and certifications can enhance earning potential. Benefits such as health insurance, retirement plans, and ...

Source: (as of 06/04/2025). Read more from

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Location Avg. Salary Date Updated
Location Saint Peters, MO Avg. Salary $100,205 Date Updated August 01, 2026
Location Adrian, MO Avg. Salary $98,855 Date Updated August 01, 2026
Location Advance, MO Avg. Salary $96,864 Date Updated August 01, 2026
Location Agency, MO Avg. Salary $100,449 Date Updated August 01, 2026
Location Alba, MO Avg. Salary $96,822 Date Updated August 01, 2026
Location Albany, MO Avg. Salary $97,158 Date Updated August 01, 2026
Location Aldrich, MO Avg. Salary $94,517 Date Updated August 01, 2026
Location Alexandria, MO Avg. Salary $97,199 Date Updated August 01, 2026
Location Allendale, MO Avg. Salary $97,359 Date Updated August 01, 2026
Location Allenton, MO Avg. Salary $100,067 Date Updated August 01, 2026
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