Principal Scientist (Technology)

We are offering an opportunity for an outstanding scientist in the predictive ADME group within the DMPK department at Genentech. You will work with our established team to further develop and deliver the vision of in vitro ADME, including the optimization of ADME properties through various in vitro assays in drug discovery and development. As a manager and scientific in vitro ADME expert, you will work in a collegial environment within DMPK and with project teams and jointly support our drug discovery portfolio. In the DMPK department, we enable both drug discovery and development projects as an integral partner in identifying compounds with superior ADME properties using state-of-the-art methodologies across diverse therapeutic areas and small molecule modalities.

Your Profile:

You have extensive experience in a wide variety of in vitro ADME assays, and deep fundamental understanding of mechanistic ADME, including a solid track record of publications in applying new science and technologies to enhance in vitro ADME assays. Your strong bio/chemistry background enables you to evaluate and interpret in vitro ADME data in the context of IVIVC/IVIVE, closely work with our partners and contribute to overall lead optimization and candidate identification strategies. You have extensive hands-on experience in various LC-MS platforms supporting in vitro ADME assays so that you can support your direct reports in their work and enable them to troubleshoot various technical issues. You are innovative and passionate for science, and you work in a collaborative and inclusive manner.

Minimum Requirements:

You have 10 years relevant in vitro ADME experience and at least 5 years in a role in supporting DMPK projects. Having a good understanding of in vivo study design and IVIVE data interpretation would be a plus. You have managed direct reports and are comfortable setting goals, managing deliverables and mentoring technical and career development. Preferably, you have had experiences in supporting novel modalities and managing in vitro ADME assays at external CROs.

About Us:

Genentech's Drug Metabolism & Pharmacokinetics (DMPK) department is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic (PK) properties of small molecule drug candidates from very early-stage research to NDA. We effectively collaborate in the development of safe and efficacious life-changing therapeutics for patients with a sense of urgency. We value our employees and foster scientific as well as professional growth. The DMPK group works in close partnership with disciplines such as medicinal chemistry, computational chemistry, informatics, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to discovery and optimize lead compounds, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Relocation benefits are available for this position.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.