What are the responsibilities and job description for the Research Fellow position at Spaulding Rehabilitation Hospital?
Summary
Under the direction of Dr. Fabrisia Ambrosio (Harvard Medical School & Spaulding Rehabilitation Hospital), the post-doctoral fellow will lead a multidisciplinary project investigating the molecular mechanisms by which aging compromises skeletal muscle health and regenerative potential.
Muscle injury often results in persistent functional declines and impaired mobility in older individuals owing in large part to impaired regenerative responses. With the goal of better understanding the mechanisms underlying these declines over time, we will: 1) investigate how aging of the skeletal muscle extracellular matrix (i.e., the scaffolding material that surrounds all cells) alters the ability of extracellular vesicles to promote functional muscle regeneration, and 2) evaluate whether and how muscle contractile activity reverses these changes. Our long-term goal is to develop novel therapeutics to enhance tissue healing in a geriatric population.
This is a collaborative project with the LeDuc laboratory at Carnegie Mellon University, and the project spans molecular/cellular biology together with bioengineering.
Key Responsibilities
The post-doctoral fellow should be willing to mentor and work closely with students and/or research technicians.
Qualifications And Experience
Education/Degree
Required: PhD
Required
Experience
Required: Must demonstrate strong verbal and written communication skills with the English language
Preferred
MA-Charlestown-SRH Spaulding Rehabilitation Hospital Boston
Work Locations
SRH Spaulding Rehabilitation Hospital Boston
Job
MD/PHD/Fellows/ PostDocs
Organization
Spaulding Hospital–Boston & Cambridge(SRN,SRH,SHC)
Schedule
Full-time
Standard Hours
40
Shift
Day Job
Employee Status
Regular
Recruiting Department
SRH Research
Job Posting
Jul 17, 2024
Under the direction of Dr. Fabrisia Ambrosio (Harvard Medical School & Spaulding Rehabilitation Hospital), the post-doctoral fellow will lead a multidisciplinary project investigating the molecular mechanisms by which aging compromises skeletal muscle health and regenerative potential.
Muscle injury often results in persistent functional declines and impaired mobility in older individuals owing in large part to impaired regenerative responses. With the goal of better understanding the mechanisms underlying these declines over time, we will: 1) investigate how aging of the skeletal muscle extracellular matrix (i.e., the scaffolding material that surrounds all cells) alters the ability of extracellular vesicles to promote functional muscle regeneration, and 2) evaluate whether and how muscle contractile activity reverses these changes. Our long-term goal is to develop novel therapeutics to enhance tissue healing in a geriatric population.
This is a collaborative project with the LeDuc laboratory at Carnegie Mellon University, and the project spans molecular/cellular biology together with bioengineering.
Key Responsibilities
- Stem cell isolation and characterization, including fluorescence activated cell sorting (FACS), sterile cell culture.
- Extracellular vesicle isolation, characterization, and manipulation of cargoes.
- Small rodent experiments, including cell transplantation, skeletal muscle functional testing, and surgical procedures.
The post-doctoral fellow should be willing to mentor and work closely with students and/or research technicians.
Qualifications And Experience
Education/Degree
Required: PhD
Required
Experience
- Wet lab experience
- Experience working with stem cells
- Experience collaborating with investigators in the fields of bioengineering and physics
- Bioinformatic skills
Required: Must demonstrate strong verbal and written communication skills with the English language
Preferred
- Highly developed communications and interpersonal skills
- Ability to work independently, be self-directed
- Willingness to contribute as a member of a team and support other projects as needed
- Anticipates challenges and develops and implements strategies for addressing them
- Demonstrate initiative with ability to prioritize work, meet deadlines and adapt to changing situations
- Attention to detail
MA-Charlestown-SRH Spaulding Rehabilitation Hospital Boston
Work Locations
SRH Spaulding Rehabilitation Hospital Boston
Job
MD/PHD/Fellows/ PostDocs
Organization
Spaulding Hospital–Boston & Cambridge(SRN,SRH,SHC)
Schedule
Full-time
Standard Hours
40
Shift
Day Job
Employee Status
Regular
Recruiting Department
SRH Research
Job Posting
Jul 17, 2024
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