Principal Product Manager jobs in the United States

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Associate Principal Engineer, Antibody Drug Conjugates - Process
  • 50085962 - Engineering Technology Manager
  • Gaithersburg, MD FULL_TIME
  • Are you ready to make a significant impact on patients' lives? As the Associate Director of Antibody Drug Conjugate (ADC) Manufacturing Process, you will be responsible for developing, characterizing, and validating conjugation and associated purification platform unit operations within our biologics Global Technical Operations (GTO). You will work closely with BioPharmaceutical Development and other members of the New Modalities Team to build the requisite technical knowledge to plan and execute activities internally and/or at third parties.

    Accountabilities:
    Your role will involve leading activities related to ADC conjugation and associated purification unit operations platforms within Biologics GTO to achieve optimized manufacturing processes regarding productivity, product quality and SHE (Safety, Health & Environmental). This will involve building the requisite technical knowledge to plan and execute the development, characterization, and validation of relevant unit operations internally and/or at third parties with other departments.

    Essential Skills/Experience:

    • Bachelor’s degree in engineering, biochemistry or related field: 12 years of experience with Bachelors degree; 9 years with Masters; and 6 years with Ph.D.

    • Minimum of ten years of significant engineering or operational experience.

    • Excellent problem-solving abilities.

    • Strong interpersonal, organizational, collaboration and communication skills.

    • Demonstrated ability to develop, characterize (involving DOEs) and validate (performance qualification) drug substance purification manufacturing processes.

    • Deep knowledge of ADC conjugation:

    • Chemistries (mabs, linkers and cytotoxic payloads), process parameters affecting yield and product quality like purity (i.e. generation of product-related substance impurities) and potency.

    • Associated purification unit operations such ultrafiltration/diafiltration (UF/DF) and various modes of chromatography (ion exchange, hydrophobic interaction, multi-mode).

    • Knowledge of current Good Manufacturing Practices (cGMPs) and relevant SHE (Safety, Health & Environmental) laws, regulations, and guidance, especially those related to the conjugation operations.

    • Experience leading a project with cross-functional internal and external teams.

    Desirable Skills/Experience:

    • -Master’s or Ph.D. degree is preferred.

    When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

    Why AstraZeneca?
    In Operations we have a big ambition. To deliver more medicines to patients, quicker and more affordably. Backed by the investment, leadership and a clear plan to get there, we bring personal dedication and out of the box thinking. We are driven by our commitment to deliver accelerated growth for AstraZeneca and to make people's lives better. It pushes us to keep building on our foundations and progressing as we turn our ever-growing and increasingly complex pipeline from molecule to medicine. Be part of evolving how we work with Lean, cutting-edge science, digitalisation and sustainable practices.

    Are you ready to embrace a long-term, varied career in a fast-paced, growing environment? With a huge variety of global opportunities and learning from other teams this is the place to embrace lifelong learning and build capabilities, setting your own direction and pace. Apply today!

    AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

    AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

  • 4 Days Ago

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Senior Product Marketing Manager
  • SpotOn: Product
  • Chicago, IL FULL_TIME
  • Product Marketing Manager In this role, you will work side-by-side with Product, Sales and Marketing to build products that are core to restaurants’ operations. You will play a crucial role in identif...
  • 4 Days Ago

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Operations Manager
  • Principal Service Solutions
  • Hillsboro, OR FULL_TIME
  • Join our dynamic team as we transform the way high-tech companies work! Principal Service Solutions is a leading technical workforce provider entrusted to safeguard the quality of operations at compan...
  • 22 Days Ago

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Assistant Site Manager
  • Principal Service Solutions
  • Dallas, TX FULL_TIME
  • Join our dynamic team as we transform the way high-tech companies work! Principal Service Solutions is a leading technical workforce provider entrusted to safeguard the quality of operations at compan...
  • 3 Days Ago

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Technical Sales Manager
  • Principal Service Solutions
  • Methuen, MN FULL_TIME
  • Join our dynamic team as we transform the way high-tech companies work! Principal Service Solutions is a leading technical workforce provider entrusted to safeguard the quality of operations at compan...
  • 1 Month Ago

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Engineering Principal Product Manager
  • General Dynamics Land Systems US
  • Sterling, MI FULL_TIME
  • About the Position: Join an agile self-motivated team responsible for the development and implementation of advanced systems for ground combat vehicles. The function of XM30 Deputy Product Manager is ...
  • 12 Days Ago

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Product Manager
  • ATCC
  • Gaithersburg, MD
  • Overview: Ready to shape the future of science and global health? ATCC, a pioneer in biomaterials manufacturing, is seek...
  • 5/21/2024 12:00:00 AM

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Manager, Product Management- Telematics
  • GEICO
  • Chevy Chase, MD
  • GEICO is looking for an accomplished, customer obsessed, and results oriented Manager, Product Management to manage and ...
  • 5/20/2024 12:00:00 AM

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Sr. Manager, Product Management- Customer Acquisition
  • GEICO
  • Chevy Chase, MD
  • GEICO is looking for an accomplished, customer obsessed, and results oriented Senior Manager, Product Management to join...
  • 5/20/2024 12:00:00 AM

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Product Manager
  • Iridium
  • McLean, VA
  • Company Overview: Iridium is an award-winning and innovative satellite communications company with bragging rights to th...
  • 5/20/2024 12:00:00 AM

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Product Manager
  • Computercraft Corporation
  • Bethesda, MD
  • Computercraft is looking for a dynamic Product Manager to join a team that helps develop and manage cutting-edge digital...
  • 5/18/2024 12:00:00 AM

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Product Manager
  • Eliassen Group
  • McLean, VA
  • **Hybrid in McLean, VA.** Our financial services client is looking for a Product Manager to join their team. We will acc...
  • 5/18/2024 12:00:00 AM

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Product Manager
  • Apex Systems
  • McLean, VA
  • Apex Systems is looking for an ideal candidate to Work with our client Hilton as a Product Manager. A Senior level manag...
  • 5/18/2024 12:00:00 AM

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Production Manager
  • TalentRemedy
  • McLean, VA
  • We are seeking a Production Manager (PDM) for our luxury remodeling client. This role is ultimately accountable for the ...
  • 5/18/2024 12:00:00 AM

Income Estimation for Principal Product Manager jobs
$143,710 to $185,769