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As of August 01, 2026, the average salary for an Informatics Nurse Specialist in Missouri is $104,605 per year, which breaks down to an hourly rate of $50.
However, an Informatics Nurse Specialist's salary can vary significantly. Here’s a look at the typical salary range:
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Informatics Nurse Specialist Salaries by Percentile
| Annual Salary |
Monthly Pay |
Weekly Pay |
Hourly Wage |
|
| 75th Percentile | $113,427 | $9,452 | $2,181 | $55 |
| Average | $104,605 | $8,717 | $2,012 | $50 |
| 25th Percentile | $94,324 | $7,860 | $1,814 | $45 |
Highmark Health - Jefferson City, MO
Saint Luke's - Kansas City, MO
Aya Healthcare - Saint Peters, MO
Hannibal Regional Healthcare System - Hannibal, MO
An Informatics Nurse Specialist's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.
Experience is a primary driver of an Informatics Nurse Specialist's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here’s how the average salary grows at different career stages:
| Levels | Salary |
|---|---|
| Clinical ... Level Informatics Nurse Specialist | $70,343 |
| Clinical ... Level Informatics Nurse Specialist | $88,352 |
| Informati... Level Informatics Nurse Specialist | $106,747 |
| Clinical ... Level Informatics Nurse Specialist | $133,366 |
| Clinical ... Level Informatics Nurse Specialist | $149,464 |
What Am I Worth?
Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Informatics Nurse Specialists. For example, consider the average annual salaries in these key locations:
Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:
For Informatics Nurse Specialist roles, the industry you choose can affect earning potential by as much as 35% (the gap between the highest and lowest paying industries). Data shows that the Healthcare and Pharmaceuticals sectors offer the strongest compensation, at 15% above the average. In contrast, Informatics Nurse Specialist positions in Biotechnology or Edu., Gov't. & Nonprofit typically offer lower base pay, as these industries often view Informatics Nurse Specialist as a support function rather than a direct revenue driver.
| Industry Sector | Average Annual Salary | Average Hourly Rate | Pay vs.Avg |
|---|---|---|---|
| Healthcare | $120,296 | $58.0 | 15% |
| Pharmaceuticals | $115,066 | $55.0 | 10% |
Understanding how an Informatics Nurse Specialist's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.
| Annual Salary | Monthly Pay | Weekly Pay | Hourly Wage | |
|---|---|---|---|---|
| 75th Percentile | $113,427 | $9,452 | $2,181 | $55 |
| Average | $104,605 | $8,717 | $2,012 | $50 |
| 25th Percentile | $94,324 | $7,860 | $1,814 | $45 |
Ready to take the next step in your career? Browse thousands of current Informatics Nurse Specialist job openings on our job board. Use the search bar below to find your perfect match.
Gables Search Group
Saint Louis, MO
Gables Search Group | Saint Louis, MO
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InstantServe LLC
Kansas City, MO
InstantServe LLC | Kansas City, MO
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BJC Healthcare
Saint Louis, MO
BJC Healthcare | Saint Louis, MO
Job Description. Additional Information About the Role. \n. \n. \n. Are you looking for a career as a. Clinical Nurse Specialist - Neurological Sciences & ... more
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BJC Healthcare
Saint Louis, MO
BJC Healthcare | Saint Louis, MO
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BJC HealthCare
Manchester, MO
BJC HealthCare | Manchester, MO
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BJC HealthCare
Manchester, MO
BJC HealthCare | Manchester, MO
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