As of March 01, 2026, the average annual salary for nurse informatics in the US is $109,769, equivalent to $53 per hour, $2,111 weekly, or $9,147 monthly. These figures, sourced from Salary.com’s real-time job posting scans, highlight competitive earning potential for nurse informatics in cities like Santa Clara, San Jose, and Fremont.
Annually Salaries for nurse informatics in the US vary widely, spanning from $91,042 to $127,816. Most professionals fall between the 25th percentile ($99,967) and 75th percentile ($119,216), while top earners (90th percentile) make $127,816 per year. This $19,249 pay gap underscores opportunities for salary growth through certifications, specialized skills like Analysis or Integrated Care, or targeting high-paying regions like District of Columbia or California.
Location and experience significantly influence earnings. For example, District of Columbia nurse informatics often earn 10.7% above national averages due to demand from Fortune 40 companies and industry startups. Professionals are advised to focus on high-growth sectors like to offset market challenges.
