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As of August 01, 2026, the average salary for a Staff Nurse in Mississippi is $73,256 per year, which breaks down to an hourly rate of $35.
However, a Staff Nurse's salary can vary significantly. Here’s a look at the typical salary range:
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Staff Nurse Salaries by Percentile
| Annual Salary |
Monthly Pay |
Weekly Pay |
Hourly Wage |
|
| 75th Percentile | $79,515 | $6,626 | $1,529 | $38 |
| Average | $73,256 | $6,105 | $1,409 | $35 |
| 25th Percentile | $68,031 | $5,669 | $1,308 | $33 |
Mississippi Sports Medicine - Jackson, MS
Jackson State University - Jackson, MS
South Central Health System - Laurel, MS
South Central Regional Medical Center - Laurel, MS
A Staff Nurse's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location and company size can directly affect your earning potential.
Your salary can change significantly depending on where you work. States with a higher cost of living and strong industrial sectors often pay more to attract Staff Nurses. For example, consider the average annual salaries in these key locations:
Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:
For Staff Nurse roles, the industry you choose can affect earning potential by as much as 35% (the gap between the highest and lowest paying industries). Data shows that the Software & Networking and Biotechnology sectors offer the strongest compensation, at 15% above the average. In contrast, Staff Nurse positions in Edu., Gov't. & Nonprofit or MFG Nondurable typically offer lower base pay, as these industries often view Staff Nurse as a support function rather than a direct revenue driver.
| Industry Sector | Average Annual Salary | Average Hourly Rate | Pay vs.Avg |
|---|---|---|---|
| Software & Networking | $84,245 | $41.0 | 15% |
| Biotechnology | $82,414 | $40.0 | 12% |
| Energy & Utilities | $78,751 | $38.0 | 7% |
| Insurance | $76,919 | $37.0 | 5% |
Understanding how a Staff Nurse's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.
| Annual Salary | Monthly Pay | Weekly Pay | Hourly Wage | |
|---|---|---|---|---|
| 75th Percentile | $79,515 | $6,626 | $1,529 | $38 |
| Average | $73,256 | $6,105 | $1,409 | $35 |
| 25th Percentile | $68,031 | $5,669 | $1,308 | $33 |
Ready to take the next step in your career? Browse thousands of current Staff Nurse job openings on our job board. Use the search bar below to find your perfect match.
South Central Health System
Laurel, MS
South Central Health System | Laurel, MS
Registered Nurse. Registered Nurse (RN). Second West (2W). Full Time. Provides nursing care through assessment, planning, implementation, and evaluation. p... more
6 Days Ago
South Central Regional Medical Center
Laurel, MS
South Central Regional Medical Center | Laurel, MS
Job Description. Job Description. Job Title. Registered Nurse (RN). Department. SCH Outpatient Infusion Services. Full Time/PRN. Full Time | Monday-Friday ... more
7 Days Ago
South Central Health System
Laurel, MS
South Central Health System | Laurel, MS
Chemotherapy Registered Nurse. Registered Nurse (RN)- Outpatient Cancer Infusion Center. Cancer Center. Full-Time. MondayFriday 8:00 AM 5:00 PM. Job Summar... more
7 Days Ago
CommCare Corporation
Jackson, MS
CommCare Corporation | Jackson, MS
Job Title. Location 1900 Chadwick Drive, Jackson, MS, 39204, United States. Base Pay $60,000.00 - $65,000.00 / Year. Employee Type Full Time. Description R... more
3 Days Ago
South Central Health System
Magee, MS
South Central Health System | Magee, MS
Job Title. Registered Nurse - Emergency Room. Job Summary. Provides evaluation of assigned patients and plans, implements, and documents nursing care. Assi... more
5 Days Ago
Blake Management Group
Ridgeland, MS
Blake Management Group | Ridgeland, MS
Staff Nurse. QSL Management is a fast-growing senior living company with ample opportunities for advancement. Our mission is to provide seniors with luxuri... more
6 Days Ago
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