Medicinal Chemist Salary in the United States

We are seeking highly motivated, skilled, and collaborative scientists to join our growing biology team. The ideal candidates will be proficient in molecular and cellular biological skills and have a passion for contributing to drug discovery. Applicants with expertise in chemical biology and molecular biology will be given priority. The candidates should enjoy working in a multi-disciplinary team comprised of biologists, translational pharmacologists, medicinal chemists, enzymologists, and DMPK experts working on the development of novel therapeutics. The ideal candidate for this role will have demonstrated success in these responsibilities: Developing and applying innovative molecular biology and chemical biology methods to enable target validation and small-molecule characterization, with a focus on cell-based assays Designing and implementing scalable assays that are integral to the identification of lead molecules Generating, analyzing, and interpreting data and communicating resu

The ideal candidates will have a deep understanding of organic reaction mechanisms, proficient organic chemistry lab skills, and a strong ability to design synthetic routes to complex molecules. Applicants with experience in small-molecule drug discovery will be given priority. The candidates should enjoy working in a multi-disciplinary team comprised of medicinal chemists, enzymologists, molecular, cell, and chemical biologists, pharmacologists and DMPK experts working on the development of novel therapeutics. The best candidates for this role will have demonstrated success in these responsibilities: Designing and implementing clear synthetic strategies towards complex molecules using innovative synthetic methodologies. Maintaining high efficiency in the laboratory setting to produce target molecules for SAR development. Implementing multiple parameter optimization strategy to advance SAR by applying medicinal chemistry knowledge and understanding of ADME, pharmacokinetics, optimal ph

Description Title: Associate or Full Researcher/ Professor (Medicinal Chemist) Position Number: 0082150 Open Date: March 02, 2023 Closing Date: Continuous Full Time/Part Time: Full Time Other Conditions: This advertisement is for a faculty position, to begin approximately Fall 2023. Associate Researcher Duties and Responsibilities: * Responsible for developing, conducting, and managing research projects in the Cancer Biology Program working with Preclinical Core, and for managing the lab, including designing drugs, assays, and performing experimental High Throughput Screening (HTS) of natural products and small-molecule libraries against validated targets and biological/biochemical processes. * Conducts molecular modeling/virtual screening in accordance with Cancer Center faculty collaboration needs; works for the overall institution's goals to discover and identify new chemical entities as drugs for clinical application. * Performs screening experiments to search for in vitro evidence

Description Newton Colmore is working with a dynamic drug discovery company dedicated to developing novel therapeutics to address unmet medical needs. They leverage cutting-edge technologies and a collaborative approach to drive advancements in drug discovery and improve patient outcomes. You will be joining a passionate team of scientists and contribute to the development of life-changing medicines. On our client's behalf we are seeking a highly skilled and motivated Medicinal Chemist to join a renowned drug discovery team. As a key member of their research group, you will play a vital role in designing and synthesizing small molecule compounds for hit identification, lead optimization, and drug development projects. You will collaborate with multidisciplinary teams, apply your expertise in medicinal chemistry, and contribute to the advancement of the company's therapeutic programs. Your responsibilities will include the synthesis of novel small molecule compounds, planning and execut

**Team Leader, Medicinal Chemistry** Boulder, Colorado / Research Chemistry / Full-Time **Who We Are** Cogent Biosciences is a biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogents lead therapeutic candidate, bezuclastinib (CGT9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. **Our Team** **The Role:** We are looking for a chemistry leader to help us build our re

We are seeking a talented undergraduate coop student to work as an organic and medicinal chemist in our lab in Cambridge, MA. Working under the general supervision of the Lab Director and from experienced lab members, the successful candidate will conduct a variety of organic chemistry synthesis experiments to prepare compounds for biological testing. This is a great opportunity for a student who is looking for practical research experience in a medicinal chemistry lab and its application to treatments for neurological diseases. PRINCIPAL DUTIES AND RESPONSIBILITIES: 1. Successfully perform organic reactions to synthesize novel drug-like compounds on small (5-10 mg) and larger (1-10g) scales including isolation of products with the appropriate use of recrystallization, column chromatography, and prep-HPLC 2. Maintain notebook and characterization data, including NMR and LC-MS spectra of new compounds 3. Develop an understanding of the structure activity relationships (SAR) for analogs