Medicinal Chemist Salary in North Carolina

Description Title: Associate or Full Researcher/ Professor (Medicinal Chemist) Position Number: 0082150 Open Date: March 02, 2023 Closing Date: Continuous Full Time/Part Time: Full Time Other Conditions: This advertisement is for a faculty position, to begin approximately Fall 2023. Associate Researcher Duties and Responsibilities: * Responsible for developing, conducting, and managing research projects in the Cancer Biology Program working with Preclinical Core, and for managing the lab, including designing drugs, assays, and performing experimental High Throughput Screening (HTS) of natural products and small-molecule libraries against validated targets and biological/biochemical processes. * Conducts molecular modeling/virtual screening in accordance with Cancer Center faculty collaboration needs; works for the overall institution's goals to discover and identify new chemical entities as drugs for clinical application. * Performs screening experiments to search for in vitro evidence

As the ASSOCIATE/DIRECTOR, COMPUTATIONAL CHEMISTRY, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Structural biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects. You will contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics. You will implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts. Responsibilities: Responsible for visibility and representation of Computational Chemistry Accomplishments to the executive team. Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment. Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success. Provide impor

Description Newton Colmore is working with a dynamic drug discovery company dedicated to developing novel therapeutics to address unmet medical needs. They leverage cutting-edge technologies and a collaborative approach to drive advancements in drug discovery and improve patient outcomes. You will be joining a passionate team of scientists and contribute to the development of life-changing medicines. On our client's behalf we are seeking a highly skilled and motivated Medicinal Chemist to join a renowned drug discovery team. As a key member of their research group, you will play a vital role in designing and synthesizing small molecule compounds for hit identification, lead optimization, and drug development projects. You will collaborate with multidisciplinary teams, apply your expertise in medicinal chemistry, and contribute to the advancement of the company's therapeutic programs. Your responsibilities will include the synthesis of novel small molecule compounds, planning and execut

**Team Leader, Medicinal Chemistry** Boulder, Colorado / Research Chemistry / Full-Time **Who We Are** Cogent Biosciences is a biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogents lead therapeutic candidate, bezuclastinib (CGT9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. **Our Team** **The Role:** We are looking for a chemistry leader to help us build our re

We are seeking a talented undergraduate coop student to work as an organic and medicinal chemist in our lab in Cambridge, MA. Working under the general supervision of the Lab Director and from experienced lab members, the successful candidate will conduct a variety of organic chemistry synthesis experiments to prepare compounds for biological testing. This is a great opportunity for a student who is looking for practical research experience in a medicinal chemistry lab and its application to treatments for neurological diseases. PRINCIPAL DUTIES AND RESPONSIBILITIES: 1. Successfully perform organic reactions to synthesize novel drug-like compounds on small (5-10 mg) and larger (1-10g) scales including isolation of products with the appropriate use of recrystallization, column chromatography, and prep-HPLC 2. Maintain notebook and characterization data, including NMR and LC-MS spectra of new compounds 3. Develop an understanding of the structure activity relationships (SAR) for analogs

About the Company: Unnatural Products (UNP) is an integrated biotech company operating at the forefront of macrocyclic peptide drug discovery. Our mission is to imbue peptide macrocycles with small molecule-like pharmacokinetic properties while maintaining high target affinity to realize their potential in drugging the entire proteome. UNP’s approach couples machine learning-based in silico tools with massively parallel peptide chemistry to enable the discovery and rapid optimization of highly non-natural macrocyclic peptides aimed at extracellular targets, undruggable intracellular oncology targets, and beyond. This strategy has enabled fruitful ongoing collaborations with Merck MSD and BridgeBio. Unnatural Products is a dynamic team of humble, brilliant, and hardworking scientists committed to changing the face of medicine. Based in Santa Cruz, CA, we do world-class science in a beautiful location and believe in work-life balance. Come join us in shaping the future of biotech! Summar