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Clinical Trial Project Manager III Salary in the United States

How much does a Clinical Trial Project Manager III make in the United States?

As of August 01, 2026, the average salary for a Clinical Trial Project Manager III in the United States is $100,840 per year, which breaks down to an hourly rate of $48.

However, a Clinical Trial Project Manager III's salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $123,211
  • Majority Range (25th-75th percentile): $89,340 to $112,550
  • Entry-Level (10th percentile): $78,870
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View as table View as graph 25% $89,340 10% $78,870 90% $123,211 75% $112,550 $100,840 50%(Median) Didn’t find job title? Click

Clinical Trial Project Manager III Salaries by Percentile

Annual
Salary
Monthly
Pay
Weekly
Pay
Hourly
Wage
75th Percentile $112,550 $9,379 $2,164 $54
Average $100,840 $8,403 $1,939 $48
25th Percentile $89,340 $7,445 $1,718 $43
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Key Factors That Influence Clinical Trial Project Manager III Salaries

A Clinical Trial Project Manager III's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location, and company size can directly affect your earning potential.

How Experience Level Affects Clinical Trial Project Manager Salaries?

Experience is a primary driver of a Clinical Trial Project Manager III's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

  • Clinical Study Project Manager I (0-2 years): $62,898
  • Clinical Study Project Manager II (2-4 years): $86,104
  • Clinical Trial Project Manager III (4-7 years): $100,833
  • Clinical Study Project Manager IV (7+ years): $114,697
  • Clinical Study Project Manager V (7-10 years): $141,619
Job Role Years of Experience Average Salary
Clinical Study Project Manager I0-2 years$62,898
Clinical Study Project Manager II2-4 years$86,104
Clinical Trial Project Manager III4-7 years$100,833
Clinical Study Project Manager IV7+ years$114,697
Clinical Study Project Manager V7-10 years$141,619
$62,898 Clinical ...
$86,104 Clinical ...
$100,833 Clinical ...
$114,697 Clinical ...
$141,619 Clinical ...
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What Am I Worth?

Top Paying Cities for Clinical Trial Project Manager IIIs

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $127,190
  • San Francisco: $125,790
  • Oakland: $123,140

Clinical Trial Project Manager III Salary by Company Size: Startups vs. Enterprise

Clinical Trial Project Manager III salary potential scales significantly with company size. Data shows that Enterprise companies (5,000+ employees) pay the highest average salary at around $114,432. While startup companies pay approximate $97,103.

Clinical Trial Project Manager III Salary by Company Size

Company Size Employees Average Salary
Startup1~50$97,103
Growth Stage51~500$102,613
Established501~5000$110,579
Enterprise5000+$114,432

Clinical Trial Project Manager III Salary by Industry: Top Paying Sectors

For Clinical Trial Project Manager III roles, the industry you choose can affect earning potential by as much as 40% (the gap between the highest and lowest paying industries). Data shows that the Biotechnology and Healthcare sectors offer the strongest compensation, at 20% above the average. In contrast, Clinical Trial Project Manager positions in Chemicals or Edu., Gov't. & Nonprofit typically offer lower base pay, as these industries often view Clinical Trial Project Manager III as a support function rather than a direct revenue driver.

The top paying industries for a Clinical Trial Project Manager III

Industry Sector Average Annual Salary Average Hourly Rate Pay vs.Avg
Biotechnology$121,008$58.020%
Healthcare$110,924$53.010%

Clinical Trial Project Manager III Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Clinical Trial Project Manager III's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

Last Updated on August 01, 2026

Clinical Trial Project Manager III Salary Growth & Career Path

For a Clinical Trial Project Manager III, the most direct path to higher earnings is advancing to the Clinical Study Project Manager IV role. This promotion typically comes with a significant pay increase, bringing the average annual salary to $114,700 - a projected growth of 14% over your current level.

Most common benefits for Clinical Trial Project Manager III

Social Security
401(k)
Disability
Healthcare
Pension
Time Off (days)
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Common company salaries for Clinical Trial Project Manager III

Here are companies hiring for Clinical Trial Project Manager III and their salaries, click below for more details.

Find Your Next Clinical Trial Project Manager III Job

Ready to take the next step in your career? Browse thousands of current Clinical Trial Project Manager III job openings on our job board. Use the search bar below to find your perfect match.

United States
  • Continuum Medical Staffing

    Columbus, OH

    Continuum Medical Staffing | Columbus, OH

    PSYCHIATRIST- CHILD/ADOLESCENT COLUMBUS OHIO We are seeking a Board-Certified Child/ Adolescent Psychiatrist for a permanent position in Columbus Ohio No V... more

    6 Days Ago

  • MD Staff, LLC

    Columbus, OH

    MD Staff, LLC | Columbus, OH

    Neurologist Locum Tenens Opportunity Near Columbus, OH. We are excited to offer a rewarding locum tenens opportunity for a Board Certified or Board Eligibl... more

    6 Days Ago

  • Confidential

    Columbus, OH

    Confidential | Columbus, OH

    Associate Vice President, Brand & External Communications. About the Company. National consulting & advisory services firm focused on the healthcare indust... more

    17 Days Ago

  • C.R. England

    Columbus, OH

    C.R. England | Columbus, OH

    Job Description. C.R. England is Now Urgently Hiring Local Dedicated CDL-A Truck Drivers. \n. Dedicated Local Fleet - Home Daily - Competitive Pay* - Full ... more

    18 Days Ago

  • Confidential

    Columbus, OH

    Confidential | Columbus, OH

    Vice President, Credit Risk Strategy & Data Science. About the Company. High-growth SMB lender building the next generation of credit decisioning. Industry... more

    18 Days Ago

  • KreilKamp Trucking

    Columbus, OH

    KreilKamp Trucking | Columbus, OH

    Regional CDL A Drivers | NEW Grads Welcome | Earn $70,000+ Annually. We're proud to be a 4th generation family truck line, started in 1935, but even proude... more

    18 Days Ago

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FAQ about Clinical Trial Project Manager III

1. What industry pays the highest salary for Clinical Trial Project Manager III?

The Biotechnology industry offers the highest average compensation for Clinical Trial Project Manager III roles, with salaries approximately 20% above the market median.

2. What is the highest salary for a clinical trial manager?

The highest salary for a Clinical Trial Project Manager is $140,160. The salary range typically starts at a minimum of $113,910, with a mid-level salary of $125,940. This data reflects the compensation structure for this role, highlighting the potential earnings in the field.

3. How much do clinical trials managers make in the US?

Clinical Trial Project Managers in the US earn between $113,910 and $140,160 annually, with a median salary of approximately $125,940. This reflects a competitive compensation range, significantly above the national average, highlighting the importance and demand for skilled professionals in this field.

4. How much do clinical project managers make in the US?

Clinical Trial Project Managers in the US earn between $113,910 and $140,160 annually, with a median salary of approximately $125,940. These figures reflect the typical salary range for this role, providing a clear overview of potential earnings in the field.

5. What is the highest paying job in clinical research?

The highest-paying job in clinical research is often the Clinical Trial Project Manager, with salaries ranging from $113,910 to $140,160, depending on experience and location. This role requires strong leadership and organizational skills, making it a lucrative option for those with the right expertise. Ultimately, the best field will align with your individual skills and interests.

6. What does a clinical trial Project Manager do?

A Clinical Trial Project Manager oversees the planning and execution of clinical trials, ensuring data integrity and compliance with safety standards. They design evaluation metrics, record data accurately, and mitigate bias in patient assignments. The salary for this role ranges from $113,910 to $140,160, with a median of $125,940, reflecting the importance of their responsibilities in the research process.

7. Is clinical trial manager a good job?

The job of a Clinical Trial Manager is very fulfilling, allowing you to impact many lives by managing clinical research studies that lead to new treatments and better disease understanding. With a salary range from $113,910 to $140,160, it offers competitive compensation, making it an attractive career choice for those passionate about healthcare and research.

Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

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