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Clinical Trial Project Manager IV Salary in the United States

How much does a Clinical Trial Project Manager IV make in the United States?

As of August 01, 2026, the average salary for a Clinical Trial Project Manager IV in the United States is $114,700 per year, which breaks down to an hourly rate of $55.

However, a Clinical Trial Project Manager IV's salary can vary significantly. Here’s a look at the typical salary range:

  • Top Earners (90th percentile): $130,347
  • Majority Range (25th-75th percentile): $105,150 to $122,890
  • Entry-Level (10th percentile): $96,455
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View as table View as graph 25% $105,150 10% $96,455 90% $130,347 75% $122,890 $114,700 50%(Median) Didn’t find job title? Click

Clinical Trial Project Manager IV Salaries by Percentile

Annual
Salary
Monthly
Pay
Weekly
Pay
Hourly
Wage
75th Percentile $122,890 $10,241 $2,363 $59
Average $114,700 $9,558 $2,206 $55
25th Percentile $105,150 $8,763 $2,022 $51
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Key Factors That Influence Clinical Trial Project Manager IV Salaries

A Clinical Trial Project Manager IV's salary isn't a fixed number. It's shaped by several important factors. Below, we'll explore how your years of experience, geographic location, and company size can directly affect your earning potential.

How Experience Level Affects Clinical Trial Project Manager Salaries?

Experience is a primary driver of a Clinical Trial Project Manager IV's salary. As you build your skills and take on more complex tasks, your compensation generally increases. Here's how the average salary grows at different career stages:

  • Clinical Study Project Manager II (2-4 years): $86,104
  • Clinical Study Project Manager III (4-7 years): $100,833
  • Clinical Trial Project Manager IV (7+ years): $114,697
  • Clinical Study Project Manager V (7-10 years): $141,619
  • Clinical Study Project Management Supervisor (10+ years): $97,243
Job Role Years of Experience Average Salary
Clinical Study Project Manager II2-4 years$86,104
Clinical Study Project Manager III4-7 years$100,833
Clinical Trial Project Manager IV7+ years$114,697
Clinical Study Project Manager V7-10 years$141,619
Clinical Study Project Management Supervisor10+ years$97,243
$86,104 Clinical ...
$100,833 Clinical ...
$114,697 Clinical ...
$141,619 Clinical ...
$97,243 Clinical ...
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Top Paying Cities for Clinical Trial Project Manager IVs

Salaries can also vary between different cities. Major metropolitan areas or cities with a high demand for technicians often offer more competitive pay. Here are a few examples of average annual salaries in different U.S. cities:

  • San Jose: $144,670
  • San Francisco: $143,090
  • Oakland: $140,070

Clinical Trial Project Manager IV Salary by Company Size: Startups vs. Enterprise

Clinical Trial Project Manager IV salary potential scales significantly with company size. Data shows that Enterprise companies (5,000+ employees) pay the highest average salary at around $130,161. While startup companies pay approximate $110,450.

Clinical Trial Project Manager IV Salary by Company Size

Company Size Employees Average Salary
Startup1~50$110,450
Growth Stage51~500$116,717
Established501~5000$125,778
Enterprise5000+$130,161

Clinical Trial Project Manager IV Salary by Industry: Top Paying Sectors

For Clinical Trial Project Manager IV roles, the industry you choose can affect earning potential by as much as 50% (the gap between the highest and lowest paying industries). Data shows that the Biotechnology and Healthcare sectors offer the strongest compensation, at 20% above the average. In contrast, Clinical Trial Project Manager positions in Edu., Gov't. & Nonprofit or Chemicals typically offer lower base pay, as these industries often view Clinical Trial Project Manager IV as a support function rather than a direct revenue driver.

The top paying industries for a Clinical Trial Project Manager IV

Industry Sector Average Annual Salary Average Hourly Rate Pay vs.Avg
Biotechnology$137,640$66.020%
Healthcare$126,170$61.010%
Pharmaceuticals$126,170$61.010%

Clinical Trial Project Manager IV Salary: Hourly Rate, Weekly Pay, and Monthly Pay

Understanding how a Clinical Trial Project Manager IV's annual salary breaks down can help with budgeting. Below, you can see the average hourly rate, weekly pay, and monthly pay for this role. Use the buttons to switch between different pay periods.

Last Updated on August 01, 2026

Clinical Trial Project Manager IV Salary Growth & Career Path

For a Clinical Trial Project Manager IV, the most direct path to higher earnings is advancing to the Clinical Study Project Manager V role. This promotion typically comes with a significant pay increase, bringing the average annual salary to $141,700 - a projected growth of 24% over your current level.

Most common benefits for Clinical Trial Project Manager IV

Social Security
401(k)
Disability
Healthcare
Pension
Time Off (days)
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Common company salaries for Clinical Trial Project Manager IV

Here are companies hiring for Clinical Trial Project Manager IV and their salaries, click below for more details.

Find Your Next Clinical Trial Project Manager IV Job

Ready to take the next step in your career? Browse thousands of current Clinical Trial Project Manager IV job openings on our job board. Use the search bar below to find your perfect match.

United States
  • Confidential

    Columbus, OH

    Confidential | Columbus, OH

    Vice President, Payments Engineering. About the Company. Globally-recognized provider of corporate payment solutions. Industry. Financial Services. Type. P... more

    21 Days Ago

  • Confidential

    Columbus, OH

    Confidential | Columbus, OH

    Senior Vice President of Project Delivery. About the Company. A multi-billion-dollar construction organization with collaborative, servant-minded leadershi... more

    21 Days Ago

  • Confidential

    Columbus, OH

    Confidential | Columbus, OH

    Chief of Staff. About the Company. Innovative travel platform for booking & managing work trips. Industry. Computer Software. Type. Privately Held, VC-back... more

    21 Days Ago

  • McDonalds

    Columbus, OH

    McDonalds | Columbus, OH

    McDonald’s is seeking Crew Team Members to assist with daily restaurant operations including customer service, food preparation, and maintaining restaurant... more

    28 Days Ago

  • Amazon Flex

    Columbus, OH

    Amazon Flex | Columbus, OH

    Amazon Flex Delivery Drivers use their own vehicle to deliver Amazon packages to customers on scheduled delivery blocks. Drivers are responsible for pickin... more

    28 Days Ago

  • Confidential

    Columbus, OH

    Confidential | Columbus, OH

    Vice President, Commercial. About the Company. Globally-recognized manufacturer of packaging components & delivery systems for injectable drugs. Industry. ... more

    1 Month Ago

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FAQ about Clinical Trial Project Manager IV

1. What industry pays the highest salary for Clinical Trial Project Manager IV?

The Biotechnology industry offers the highest average compensation for Clinical Trial Project Manager IV roles, with salaries approximately 20% above the market median.

2. How much do clinical project managers make in the US?

Clinical Trial Project Managers in the US earn between $139,800 and $165,550 annually, with a median salary of approximately $152,380. These figures reflect the competitive compensation in this field, highlighting the value of expertise and experience in managing clinical trials effectively.

3. Can you make 6 figures as a project manager?

Yes, you can definitely make six figures as a Clinical Trial Project Manager. With a minimum salary of $139,800, a mid-range salary of $152,380, and a maximum salary of $165,550, reaching a six-figure income is not only achievable but also realistic. It requires dedication, experience, and the right opportunities to attain such compensation.

4. What is the highest paying job in clinical research?

The highest-paying job in clinical research is often the Clinical Trial Project Manager, with salaries ranging from $139,800 to $165,550, depending on experience and expertise. While roles in biostatistics, regulatory affairs, and pharmacovigilance are also lucrative, the best fit for you will depend on your individual skills and interests.

5. Is clinical trial manager a good job?

The job of a Clinical Trial Manager is very fulfilling, allowing you to impact many lives by managing clinical research studies that lead to new treatments and better disease understanding. With a salary range from $139,800 to $165,550, it offers competitive compensation, making it an attractive career choice for those passionate about healthcare and research.

6. Which clinical trials pay the most money?

Clinical trials in therapeutic areas such as cardiovascular disease, neurology, endocrine, gastrointestinal, and blood disorders typically offer the highest compensation. For Clinical Trial Project Managers, salaries range from a minimum of $139,800 to a maximum of $165,550, with a mid-salary of $152,380. However, participation in these trials often requires specific commitments.

7. Do you need a PHD to be a clinical trial manager?

A bachelor's degree is generally required to work as a clinical trial manager, with majors in clinical trial administration, health science, biology, pre-med, or business. The salary for a Clinical Trial Project Manager typically ranges from $139,800 to $165,550, with a median salary around $152,380. Advanced degrees may enhance career prospects but are not mandatory.

Where Does Our Salary Data Come From?

Salary.com provides salary estimates, histograms, trends, and comparisons using data from employer job postings and third-party sources.

We offer detailed salary information across multiple percentiles for your reference. (Click here to learn Why the Salary Midpoint Formula Is Crucial for Achieving Pay Equity.)

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