How much does a Nurse, RN make in Roanoke, VA? The average Nurse, RN salary in Roanoke, VA is $66,536 as of April 01, 2025, but the salary range typically falls between $60,317 and $75,039. Salary ranges can vary widely depending on many important factors, including education, certifications, additional skills, the number of years you have spent in your profession. With more online, real-time compensation data than any other website, Salary.com helps you determine your exact pay target.
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