How much does a Senior Principal Scientist make in Mesa, AZ? The average Senior Principal Scientist salary in Mesa, AZ is $178,201 as of April 01, 2025, but the salary range typically falls between $160,078 and $194,446. Salary ranges can vary widely depending on many important factors, including education, certifications, additional skills, the number of years you have spent in your profession. With more online, real-time compensation data than any other website, Salary.com helps you determine your exact pay target.
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